Fungicide composition comprising a tetrazolyloxime derivative and a thiazolylpiperidine derivative

ABSTRACT

The present invention relates to a pesticide composition intended for protecting plants, crops or seeds against fungal diseases or insect damages, and the corresponding methods of protection by application of the said composition. More precisely, the subject of the present invention is a pesticide composition based on a tetrazolyloxime derivative and a thiazolylpiperidine derivative, which may further comprise another fungicide and/or an insecticide active substance or compound.

CROSS REFERENCE TO RELATED APPLICATION(S)

The present application is a 35 U.S.C. §371 national phase conversion of PCT/EP2011/067424 filed on Oct. 6, 2011, which claims priority to European Application No. 10356026.4 filed on Oct. 7, 2010 and U.S. Provisional Application No. 61/414,617 filed on Nov. 17, 2010. Applicants claim priority to each of the foregoing patent applications. The PCT International Application was published in the English language.

DESCRIPTION

The present invention relates to a pesticide composition intended for protecting plants, crops or seeds against fungal diseases or insect damages, and the corresponding methods of protection by application of the said composition. More precisely, the subject of the present invention is a pesticide composition based on a tetrazolyloxime derivative and a thiazolylpiperidine derivative, which may further comprise another fungicide and/or an insecticide active substance or compound.

As regards pesticide activity, in particular for the protection of crops, one of the problems at the heart of the research studies carried out in this technical field is the improvement of performances, in particular in terms of biological activity and in particular in terms of maintaining such an activity over time.

The present invention provides a pesticide composition which can be used, in particular by the farmer, for controlling the pest infesting crops and in particular for controlling insects or diseases.

The pesticide compounds useful for the protection of plants must be endowed with an ecotoxicity which is reduced to the minimum. As far as possible, they should not be dangerous or toxic to the operator during use. The economic factor should of course not be overlooked in the search for novel pesticide agents.

The present invention advantageously provides a pesticide composition which is completely high-performing in particular as regards its efficacy against pests and the perennially of this efficacy so as to be able to reduce the doses of chemical products spread in the environment for combating pest damages or attacks of plants or crops.

The invention provides a pesticide composition capable to be more active and active for longer, and which therefore has a lower dose, but which is also less toxic, in particular in the treatment of plants and particularly the foliar and seed treatments of fungal diseases or the control of insects, for example, of cereals, cotton, peanut, bean, beet, canola, Solanaceae, grapevine, vegetables, lucerne, soybean, market garden crops, turf, wood or horticultural plants.

The composition according to the invention allows controlling a broad variety of insects or fungi. For example, the pesticide composition according to the invention exhibits an improved efficacy against fungus like Plasmodiophoromycetes, Oomycetes, Chytridiomycetes, Zygomycetes, Basidiomycetes, Deuteromycetes and Ascomycetes.

All these objectives or advantages, among others, were achieved by finding a pesticide composition comprising a tetrazolyloxime derivative and a thiazolylpiperidine derivative, which may further comprise an other fungicide and/or an insecticide active substance or compound. Such a composition surprisingly and unexpectedly allows a very high and perennial anti-fungal or insecticide efficacy against a broad spectrum of insects or fungi and in particular against those responsible for diseases or damages of crops. Other insect pests or diseases of crops can be controlled with the pesticide composition according to the invention.

The pesticide composition according to the invention may also be used for the treatment of bacterial or virus diseases.

Insects or nematodes that can be controlled with the pesticide composition according to the invention include a broad variety of these damaging organisms.

In patent application US-2005/0070439 there are disclosed certain tetrazolyloxime derivatives. The possibility to mix said compounds with other chemicals is generally mentioned. However, there is no specific disclosure in this document of any combination comprising said tetrazolyloxime derivatives with a fungicide compound.

In patent applications WO-2009/119072 and WO-2010/094728, there are disclosed certain tetrazolyloxime derivatives for which the possibility to mix said compounds with other chemicals is mentioned. However, there is no specific disclosure in this document of any combination comprising said tetrazolyloxime derivatives with a thiazolylpiperidine derivative.

In patent application WO-2008/013925 there are disclosed certain thiazolylopiperidine derivatives. The possibility to mix said compounds with other chemicals is generally mentioned. However, there is no specific disclosure in this document of any combination comprising said tetrazolyloxime derivatives with a fungicide compound.

In patent application WO-2009/055514, there are disclosed certain thiazolylpiperidine derivatives for which the possibility to mix said compounds with other chemicals is mentioned. However, there is no specific disclosure in this document of any combination comprising said thiazolylpiperidine derivatives with a tetrazolyloxime derivative.

In a main aspect, the present invention provides a composition comprising:

-   -   A) a tetrazolyloxime derivative of formula (I)

wherein

-   -   R independently represents a hydrogen atom, a halogen atom, a         substituted or non-substituted C₁-C₆-alkyl, a substituted or         non-substituted C₁-C₆-alkoxy, nitro, cyano, a substituted or         non-substituted C₁-C₆-aryl or a substituted or non-substituted         C₁-C₆-alkylsulfonyl;     -   q represents 0, 1, 2, 3, 4 or 5;     -   A represents a tetrazoyl group of formula (A) or (A²):

-   -   wherein Y represents an C₁-C₆-alkyl group; and     -   D represents a pyridyl group of formula (D¹) or a thiazolyl         group of formula (D²);

-   -   wherein R² and R³ independently represent a hydrogen atom, a         halogen atom, a substituted or non-substituted C₁-C₈-alkyl,         nitro, cyano, a hydroxy group, a mercapto group, formyl,         hydroxycarbonyl, a substituted or non-substituted amino, a         substituted or non-substituted C₂-C₈-alkenyl, a substituted or         non-substituted C₂-C₈-alkynyl, a substituted or non-substituted         aryl, a substituted or non-substituted heterocyclyl, OR^(a),         S(O)_(r)R^(a), COR^(a) or CO₂R^(a); wherein R^(a) represents a         substituted or non-substituted C₁-C₈-alkyl, a substituted or         non-substituted amino, a substituted or non-substituted         C₃-C₈-cycloalkyl, a substituted or non-substituted         C₂-C₈-alkenyl, a substituted or non-substituted C₂-C₈-alkynyl, a         substituted or non-substituted aryl; wherein, r represents 0, 1         or 2;     -   wherein n represents 0, 1, 2 or 3;     -   wherein Z represents Q¹CONH—, wherein represents a substituted         or non-substituted C₁-C₈-alkyl, a substituted or non-substituted         C₁-C₈-alkoxy, a substituted or non-substituted C₂-C₈-alkynyloxy;     -   as well as salts, N-oxides, metallic complexes and metalloidic         complexes thereof or (E) and (Z) isomers and mixtures thereof         -   and         -   B) a thiazolylpiperidine derivative of formula (II)

wherein

-   -   R⁴ independently represents a hydrogen atom, a halogen atom, a         C₁-C₈-alkyl, a C₁-C₈-alkoxy, a C₁-C₈-haloalkyl comprising         between one and 5 halogen atoms, cyano;     -   u represents 1, 2, 3, 4 or 5;         -   as well as salts, N-oxides, metallic complexes and             metalloidic complexes thereof or optically active isomers             and mixtures thereof             in an A/B weight ratio ranging from 1,000/1 to 1/1,000.

Any of the compounds according to the invention can exist as one or more stereoisomers depending on the number of stereogenic units (as defined by the IUPAC rules) in the compound. The invention thus relates equally to all the stereoisomers, and to the mixtures of all the possible stereoisomers, in all proportions. The stereoisomers can be separated according to the methods which are known per se by the man ordinary skilled in the art.

Notably, the stereostructure of the oxime moiety present in the tetrazolyloxime derivative of formula (I) includes (E) or (Z) isomer, and these stereoisomers form part of the present invention.

According to the invention, the following generic terms are generally used with the following meanings:

-   -   halogen means fluorine, chlorine, bromine or iodine     -   heteroatom can be nitrogen, oxygen or sulfur;     -   unless indicated otherwise, a group or a substituent that is         substituted according to the invention can be substituted by one         or more of the following groups or atoms: a halogen atom, a         nitro group, a hydroxy group, a cyano group, an isocyano group,         an isocyanate group, an thiocyanate group, an amino group, a         sulfenyl group, a formyl group, a formyloxy group, a carbamoyl         group, a C₁-C₈-alkyl, a C₁-C₈-halogenoalkyl having 1 to 5         halogen atoms, a C₂-C₈-alkenyl, a C₂-C₈-alkynyl, a         C₂-C₈-alkenyloxy, a C₁-C₈-alkylamino, a di-C₁-C₈-alkylamino, a         phenylamino, a benzylamino, a phenethylamino, a C₁-C₈-alkoxy, a         C₁-C₈-halogenoalkoxy having 1 to 5 halogen atoms, a         C₁-C₈-alkylsulfenyl, a C₁-C₈-alkylcarbonyl, a         C₁-C₈-alkylthiocarbonyl, a C₁-C₈-alkylcarbamoyl, a         di-C₁-C₈-alkylcarbamoyl, a C₁-C₈-alkoxycarbonyl, a         C₁-C₈-alkylcarbonyloxy, a C₁-C₈-alkylcarbonylamino,         C₁-C₈-alkoxycarbonylamino, a C₁-C₈-alkylsulfenyl, a         C₁-C₈-alkylsulfonyl, a C₂-C₈-alkenylsulfonyl, a         C₈-C₈-alkynylsulfonyl, aryl-sulfonyl, saturated or unsaturated         4-, 5-, 6- or 7-membered heterocyclylsulfonyl,         aryl-[C₁-C₅]-alkylsulfonyl, a C₁-C₈-alkylsulfamoyl, a         C₁-C₈-halogenoalkyl sulfamoyl having 1 to 5 halogen atoms, a         N-di(C₁-C₈-alkyl)sulfamoyl, a N-di(C₁-C₈-halogenoalkyl)sulfamoyl         having 1 to 5 halogen atoms, arylsulfamoyl, saturated or         unsaturated 4-, 5-, 6- or 7-membered heterocyclylsulfamoyl         aryl-[C₁-C₈]-alkyl, saturated or unsaturated 4-, 5-, 6- or         7-membered heterocyclyl-[C₁-C₈]-alkyl comprising up to 4         heteroatoms selected in the list consisting of N, O, S,         aryl-[C₁-C₈]-alkoxy, aryloxy, aryl,         (C₁-C₈-alkylimino)-C₁-C₈-alkyl, saturated or unsaturated 4-, 5-,         6- or 7-membered heterocyclyl, aryl-[C₁-C₈]-alkylthio, arylthio,         saturated or unsaturated 4-, 5-, 6- or 7-membered         heterocyclylthio;     -   the term “aryl” means phenyl or naphthyl     -   the term “heterocyclyl” means saturated or unsaturated 4-, 5-,         6- or 7-membered heterocyclyl.

In a further aspect, the present invention provides a composition comprising:

-   -   A) a tetrazolyloxime derivative of formula (I) wherein         formula (I) is as herein-defined ;     -   B) a thiazolylpiperidine derivative of, formula (II) wherein         formula (II) is, as, herein-defined and     -   C) a third further fungicide compound in an A/B/C weight ratio         ranging from 1,000/1,000/1 to 1/1,000/1,000.

Still in a further aspect, the present invention provides a composition comprising:

-   -   A) a tetrazolyloxime derivative of formula (I) wherein         formula (I) is as herein-defined;     -   B) a thiazolylpiperidine derivative of formula (II)) wherein         formula (II) is as herein-defined and     -   D) an insecticide compound in an A/B/D weight ratio ranging from         1,000/1,000/1 to 1/1,000/1,000.

Still in a further aspect, the present invention provides a composition comprising:

-   -   A) a tetrazolyloxime derivative of formula (I) wherein         formula (I) is as herein-defined;     -   B) a thiazolylpiperidine derivative of formula (II) wherein         formula (II) is as herein-defined;     -   C) a third further fungicide compound and     -   D) an insecticide compound in an A/B/C/D weight ratio ranging         from 1,000/1,000/1,000/1 to 1/1,000/1,000/1,000.

In the tetrazolyloxime derivative of formula (I), the substitution position of R¹ is not specifically limited and R¹ represents preferentially a hydrogen atom, a halogen atom, a substituted or non-substituted C₄-C₆-alkyl, a substituted or non-substituted C₁-C₆-alkoxy.

The alkyl group represented for R¹ is preferably an alkyl group having 1 to 4 carbon atoms and specific examples thereof include a methyl group, an ethyl group, a n-propyl group, an isopropyl group, a n-butyl group, an isobutyl group, a sec-butyl group, and a tert-butyl group. Among these alkyl groups, a methyl group or a tert-butyl group is particularly preferred.

The C₁-C₈-alkoxy group for R¹ is preferably alkoxy group having 1 to 3 carbon atoms and specific examples thereof include a methoxy group, an ethoxy group, a propoxy group, and an isopropoxy group. Among these alkoxy groups, a methoxy group or an ethoxy group is particularly preferred.

R¹ represents more preferentially a hydrogen atom or a halogen atom.

In the tetrazoyl group of formula (A¹) or (A²), Y represents an alkyl group. Among these alkyl groups, an alkyl group having 1 to 3 carbon atoms such as a methyl group, an ethyl group, a n-propyl group or an isopropyl group is preferable. Among these alkyl groups, a methyl group is particularly preferred.

R² and R³ independently represent preferentially a hydrogen atom or a halogen atom.

For the tetrazolyloxime derivative of formula (I), preference is further given to but-3-yn-1-yl{6-[({[(Z)-(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate (compound A1) and to

tert-butyl{6-({[(Z)-(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate (compound A2)

The stereostructure of the oxime moiety present in the tetrazolyloxime derivative of formula (I) includes (E) or (Z) isomer, and these stereoisomers form part of the present invention. The synthesized product is generally obtained in the, form of the (Z) isomer or a mixture of (E) and (Z) isomers, each of which can be isolated by separation or purification.

In the tetrazolyloxime derivative of formula (I), the (Z) isomer is particularly superior to the (E) isomer in plant disease controlling activity. However, both the (E) isomer and the (Z) isomer generally exist in a fixed ratio in the form of a mixture since the (Z) isomer is generally converted into the (E) isomer by light in a natural environment. The stable ratios of the (E) and (Z) isomers vary according to the type of compound.

In the thiazolylpiperidine derivative of formula (II), R⁴ represents preferentially a hydrogen atom or a halogen atom. More preferably, R⁴ represents preferentially a hydrogen atom or a fluorine

For thiazolylpiperidine derivative of formula (II), preference is further given to 2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-(5-phenyl-4,5-dihydro-1,2-oxazol-3-yl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone (compound B1) and to

1-(4-{4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (compound B2)

For the different aspects of the composition according to the invention, fungicide compounds C can be independently selected in the list consisting of:

(1) Inhibitors of the ergosterol biosynthesis, for example (1.1) aldimorph (1704-28-5), (1.2) azaconazole (60207-31-0), (1.3) bitertanol (55179-31-2), (1.4) bromuconazole (116255-48-2), (1.5) cyproconazole (113096-99-4), (1.6) diclobutrazole (75736-33-3), (1.7) difenoconazole (119446-68-3), (1.8) diniconazole (83657-24-3), (1.9) diniconazole-M (83657-18-5), (1.10) dodemorph (1593-77-7), (1.11) dodemorph acetate (31717-87-0), (1.12) epoxiconazole (106325-08-0), (1.13) etaconazole (60207-93-4), (1.14) fenarimol (60168-88-9), (1.15) fenbuconazole (114369-43-6), (1.16) fenhexamid (126833-17-8), (1.17) fenpropidin (67306-00-7), (1.18) fenpropimorph (67306-03-0), (1.19) fluquinconazole (136426-54-5), (1.20) flurprimidol (56425-91-3), (1.21) flusilazole (85509-19-9), (1.22) flutriafol (76674-21-0), (1.23) furconazole (112839-33-5), (1.24) furconazole-cis (112839-32-4), (1.25) hexaconazole (79983-71-4), (1.26) imazalil (60534-80-7), (1.27) imazalil sulfate (58594-72-2), (1.28) imibenconazole (86598-92-7), (1.29) ipconazole (125225-28-7), (1.30) metconazole (125116-23-6), (1.31) myclobutanil (88671-89-0), (1.32) naftifine (65472-88-0), (1.33) nuarimol (63284-71-9), (1.34) oxpoconazole (174212-12-5), (1.35) paclobutrazol (76738-62-0), (1.36) pefurazoate (101903-30-4), (1.37) penconazole (66246-88-6), (1.38) piperalin (3478-94-2), (1.39) prochloraz (67747-09-5), (1.40) propiconazole (60207-90-1), (1.41) prothioconazole (178928-70-6), (1.42) pyributicarb (88678-67-5), (1.43) pyrifenox (88283-41-4), (1.44) quinconazole (103970-75-8), (1.45) simeconazole (149508-90-7), (1.46) spiroxamine (118134-30-8), (1.47) tebuconazole (107534-96-3), (1.48) terbinafine (91161-71-6), (1.49) tetraconazole (112281-77-3), (1.50) triadimefon (43121-43-3), (1.51) triadimenol (89482-17-7), (1.52) tridemorph (81412-43-3), (1.53) triflumizole (68694-11-1), (1.54) triforine (26644-46-2), (1.55) triticonazole (131983-72-7), (1.56) uniconazole (83657-22-1), (1.57) uniconazole-p (83657-17-4), (1.58) viniconazole (77174-66-4), (1.59) voriconazole (137234-62-9), (1.60) 1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cycloheptanol (129586-32-9), (1.61) methyl 1-(2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-1H-imidazole-5-carboxylate (110323-95-0), (1.62) N′-{5-(difluoromethyl)-2-methyl-443-(trimethylsilyl)propoxy]phenyl}-N-ethyl-N-methylimidoformamide, (1.63) N-ethyl-N-methyl-N′-{2-methyl-5-(trifluoromethyl)-4-[3-(trimethylsilyl)propoxy]phenyl}imidoformamide and (1.64) O-[1-(4-methoxyphenoxy)-3,3-dimethylbutan-2-yl]1H-imidazole-1-carbothioate (111226-71-2).

(2) inhibitors of the respiratory chain at complex I or II, for example (2.1) bixafen (581809-46-3), (2.2) boscalid (188425-85-6), (2.3) carboxin (5234-68-4), (2.4) diflumetorim (130339-07-0), (2.5) fenfuram (24691-80-3), (2.6) fluopyram (658066-35-4), (2.7) flutolanil (66332-96-5), (2.8) fluxapyroxad (907204-31-3), (2.9) furametpyr (123572-88-3), (2.10) furmecyclox (60568-05-0), (2.11) isopyrazam (mixture of syn-epimeric racemate 1RS,4SR,9RS and anti-epimeric racemate 1RS,4SR,9SR) (881685-58-1), (2.12) isopyrazam (anti-epimeric racemate 1RS,4SR,9SR), (2.13) isopyrazam (anti-epimeric enantiomer 1R,4S,9S), (2.14) isopyrazam (anti-epimeric enantiomer 1S,4R,9R), (2.15) isopyrazam (syn epimeric racemate 1RS,4SR,9RS), (2.16) isopyrazam (syn-epimeric enantiomer 1R,4S,9R), (2.17) isopyrazam (syn-epimeric enantiomer 1S,4R,9S), (2.18) mepronil (55814-41-0), (2.19) oxycarboxin (5259-88-1), (2.20) penflufen (494793-67-8), (2.21) penthiopyrad (183675-82-3), (2.22) sedaxane (874967-67-6), (2.23) thifluzamide (130000-40-7), (2.24) 1-methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, (2.25) 3-(difluoromethyl)-1-methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-1H-pyrazole-4-carboxamide, (2.26) 3-(difluoromethyl)-N-[4-fluoro-2-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-1-methyl-1H-pyrazole-4-carboxamide, (2.27) N-[1-(2,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide (1092400-95-7) (WO 2008148570), (2.28) 5,8-difluoro-N-[2-(2-fluoro-4-([4-(trifluoromethyl)pyridin-2-yl]oxylphenyl)ethyl]quinazolin-4-amine (1210070-84-0) (WO2010025451), (2.29) N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.30) N-[(1S,4R)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide and (2.31) N-[(1R,4S)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide.

(3) inhibitors of the respiratory chain at complex Ill, for, example (3.1) ametoctradin (865318-97-4), (3.2) amisulbrom (348635-87-0), (3.3) azoxystrobin (131860-33-8), (3.4) cyazofamid (120116-88-3), (3.5) coumethoxystrobin (850881-30-0), (3.6) coumoxystrobin (850881-70-8), (3.7) dimoxystrobin (141600-52-4), (3.8) enestroburin (238410-11-2) (WO 2004/058723), (3.9) famoxadone (131807-57-3) (WO 2004/058723), (3.10) fenamidone (161326-34-7) (WO 2004/058723), (3.11) fenoxystrobin (918162-02-4), (3.12) fluoxastrobin (361377-29-9) (WO 2004/058723), (3.13) kresoxim-methyl (143390-89-0) (WO 2004/058723), (3.14) metominostrobin (133408-50-1) (WO 2004/058723), (3.15) orysastrobin (189892-69-1) (WO 2004/058723), (3.16) picoxystrobin (117428-22-5) (WO 2004/058723), (3.17) pyraclostrobin (175013-18-0) (WO 2004/058723), (3.18) pyrametostrobin (915410-70-7) (WO 2004/058723), (3.19) pyraoxystrobin (862588-11-2) (WO 2004/058723), (3.20) pyribencarb (799247-52-2) (WO 2004/058723), (3.21) triclopyricarb (902760-40-1), (3.22) trifloxystrobin (141517-21-7) (WO 2004/058723), (3.23) (2E)-2-(2-{[6-(3-chloro-2-methylphenoxy)-5-fluoropyrimidin-4-yl]oxy}phenyl)-2-(methoxyimino)-N-methylethanamide (WO 2004/058723), (3.24) (2E)-2-(methoxyimino)-N-methyl-2-(2-{[({(1E)-1-[3-(trifluoromethyl)phenyl]ethylidene}amino)oxy]methyl}phenyl)ethanamide (WO 2004/058723), (3.25) (2E)-2-(methoxyimino)-N-methyl-2-{2-[(E)-({1-[3-(trifluoromethyl)phenyl]ethoxy}imino)methyl]phenyl}ethanamide (158169-73-4), (3.26) (2E)-2-{2-[({[(1E)-1-(3-{[(E)-1-fluoro-2-phenylethenyl]oxy}phenyl)ethylidene]amino}oxy)methyl]Phenyl)-2-(methoxyimino)-N-methylethanamide (326896-28-0), (3.27) (2E)-2-{2-[({[(2E,3E)-4-(2,6-dichlorophenyl)but-3-en-2-ylidene]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N-methylethanamide, (3.28) 2-chloro-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)pyridine-3-carboxamide (119899-14-8), (3.29) 5-methoxy-2-methyl-4-(2-{[({(1E)-1-[3-(trifluoromethyl)phenyl]ethylidene}amino)oxy]methyl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one, (3.30) methyl (2E)-2-{2-[({cyclopropyl[(4-methoxyphenyl)imino]methyl}sulfanyl)methyl]phenyl}-3-methoxyprop-2-enoate (149601-03-6), (3.31) N-(3-ethyl-3,5,5-trimethylcyclohexyl)-3-(formylamino)-2-hydroxybenzamide (226551-21-9), (3.32)2424(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide (173662-97-0) and (3.33) (2R)-2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide (394657-24-0).

(4) Inhibitors of the mitosis and cell division, for example (4.1) benomyl (17804-35-2), (4.2) carbendazim (10605-21-7), (4.3) chlorfenazole (3574-96-7), (4.4) diethofencarb (87130-20-9), (4.5) ethaboxam (162650-77-3), (4.6) fluopicolide (239110-15-7), (4.7) fuberidazole (3878-19-1), (4.8) pencycuron (66063-05-6), (4.9) thiabendazole (148-79-8), (4.10) thiophanate-methyl (23564-05-8), (4.11) thiophanate (23564-06-9), (4.12) zoxamide (156052-68-5), (4.13) 5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine (214706-53-3) and (4.14) 3-chloro-5-(6-chloropyridin-3-yl)-6-methyl-4-(2,4,6-trifluorophenyl)pyridazine (1002756-87-7).

(5) Compounds capable to have a multisite action, like for example (5.1) bordeaux mixture (8011-63-0), (5.2) captafol (2425-06-1), (5.3) captan (133-06-2) (WO 02/12172), (5.4) chlorothalonil (1897-45-6), (5.5) copper hydroxide (20427-59-2), (5.6) copper naphthenate (1338-02-9), (5.7) copper oxide (1317-39-1), (5.8) copper oxychloride (1332-40-7), (5.9) copper(2+) sulfate (7758-98-7), (5.10) dichlofluanid (1085-98-9), (5.11) dithianon (3347-22-6), (5.12) dodine (2439-10-3), (5.13) dodine free base, (5.14) ferbam (14484-64-1), (5.15) fluorofolpet (719-96-0), (5.16) folpet (133-07-3), (5.17) guazatine (108173-90-6), (5.18) guazatine acetate, (5.19) iminoctadine (13516-27-3), (5.20) iminoctadine albesilate (169202-06-6), (5.21) iminoctadine triacetate (57520-17-9), (5.22) mancopper (53988-93-5), (5.23) mancozeb (8018-01-7), (5.24) maneb (12427-38-2), (5.25) metiram (9006-42-2), (5.26) metiram zinc (9006-42-2), (5.27) oxine-copper (10380-28-6), (5.28) propamidine (104-32-5), (5.29) propineb (12071-83-9), (5.30) sulfur and sulfur preparations including calcium polysulfide (7704-34-9), (5.31) thiram (137-26-8), (5.32) tolylfluanid (731-27-1), (5.33) zineb (12122-67-7) and (5.34) ziram (137-30-4).

(6) Compounds capable, to induce a host defence, for example (6.1) acibenzolar-S-methyl (135158-54-2), (6.2) isotianil (224049-04-1), (6.3) probenazole (27605-76-1) and (6.4) tiadinil (223580-51-6).

(7) Inhibitors of the amino acid and/or protein biosynthesis, for example (7.1) andoprim (23951-85-1), (7.2) blasticidin-S (2079-00-7), (7.3) cyprodinil (121552-61-2), (7.4) kasugamycin (6980-18-3), (7.5) kasugamycin hydrochloride hydrate (19408-46-9), (7.6) mepanipyrim (110235-47-7), (7.7) pyrimethanil (53112-28-0) and (7.8) 3-(5-fluoro-3,3,4,4-tetramethyl-3,4-dihydroisoquinolin-1-yl)quinoline (861647-32-7) (VV02005070917).

(8) Inhibitors of the ATP production, for example (8.1) fentin acetate (900-95-8), (8.2) fentin chloride (639-58-7), (8.3) fentin hydroxide (76-87-9) and (8.4) silthiofam (175217-20-6).

(9) Inhibitors of the cell wall synthesis, for example (9.1) benthiavalicarb (177406-68-7), (9.2) dimethomorph (110488-70-5), (9.3) flumorph (211867-47-9), (9.4) iprovalicarb (140923-17-7), (9.5) mandipropamid (374726-62-2), (9.6) polyoxins (11113-80-7), (9.7) polyoxorim (22976-86-9), (9.8) validamycin A (37248-47-8) and (9.9) valifenalate (283159-94-4; 283159-90-0).

(10) Inhibitors of the lipid and membrane synthesis, for example (10.1) biphenyl (92-52-4), (10.2) chloroneb (2675-77-6), (10.3) dicloran (99-30-9), (10.4) edifenphos (17109-49-8), (10.5) etridiazole (2593-15-9),:(10.6) iodocarb (55406-53-6), (10.7) iprobenfos (26087-47-8), (10.8) isoprothiolane (50512-35-1), (10.9) propamocarb (25606-41-1), (10.10) propamocarb hydrochloride (25606-41-1), (10.11) prothiocarb (19622-08-3), (10.12) pyrazophos (13457-18-6), (10.13) quintozene (82-68-8), (10.14) tecnazene (117-18-0) and (10.15) tolclofos-methyl (57018-04-9).

(11) Inhibitors of the melanine biosynthesis, for example (11.1) carpropamid (104030-54-8), (11.2) diclocymet (139920-32-4), (11.3) fenoxanil (115852-48-7), (11.4) phthalide (27355-22-2), (11.5) pyroquilon (57369-32-1), (11.6) tricyclazole (41814-78-2) and (11.7) 2,2,2-trifluoroethyl (3-methyl-1-[(4-methylbenzoyl)amino]butan-2-yl}carbamate (851524-22-6) (WO2005042474).

(12) Inhibitors of the nucleic acid synthesis, for example (12.1) benalaxyl (71626-11-4), (12.2) benalaxyl-M (kiralaxyl) (98243-83-5), (12.3) bupirimate (41483-43-6), (12.4) clozylacon (67932-85-8), (12.5) dimethirimol (5221-53-4), (12.6) ethirimol (23947-60-6), (12.7) furalaxyl (57646-30-7), (12.8) hymexazol (10004-44-1), (12.9) metalaxyl (57837-19-1), (12.10) metalaxyl-M (mefenoxam) (70630-17-0), (12.11) ofurace (58810-48-3), (12.12) oxadixyl (77732-09-3) and (12.13) oxolinic acid (14698-29-4).

(13) Inhibitors of the signal transduction, for example (13.1) chlozolinate (84332-86-5), (13.2) fenpiclonil (74738-17-3), (13.3) fludioxonil (131341-86-1), (13.4) iprodione (36734-19-7), (13.5) procymidone (32809-16-8), (13.6) quinoxyfen (124495-18-7) and (13.7) vinclozolin (50471-44-8).

(14) Compounds capable to act as an uncoupler, for example (14.1) binapacryl (485-31-4), (14.2) dinocap (131-72-6), (14.3) ferimzone (89269-64-7), (14.4) fluazinam (79622-59-6) and (14.5) meptyldinocap (131-72-6).

(15) Further compounds, for example (15.1) benthiazole (21564-17-0), (15.2) bethoxazin (163269-30-5), (15.3) capsimycin (70694-08-5), (15.4) carvone (99-49-0), (15.5) chinomethionat (2439-01-2), (15.6) pyriofenone (chlazafenone) (688046-61-9), (15.7) cufraneb (11096-18-7), (15.8) cyflufenamid (180409-60-3), (15.9) cymoxanil (57966-95-7), (15.10) cyprosulfamide (221667-31-8), (15.11) dazomet (533-74-4), (15.12) debacarb (62732-91-6), (15.13) dichlorophen (97-23-4), (15.14) diclomezine (62865-36-5), (15.15) difenzoquat (49866-87-7), (15.16) difenzoquat methylsulfate (43222-48-6), (15.17) diphenylamine (122-39-4), (15.18) ecomate, (15.19) fenpyrazamine (473798-59-3), (15.20) flumetover (154025-04-4), (15.21) fluoroimide (41205-21-4), (15.22) flusulfamide (106917-52-6), (15.23) flutianil (304900-25-2), (15.24) fosetyl-aluminium (39148-24-8), (15.25) fosetyl-calcium, (15.26) fosetyl-sodium (39148-16-8), (15.27) hexachlorobenzene (118-74-1), (15.28) irumamycin (81604-73-1), (15.29) methasulfocarb (66952-49-6), (15.30) methyl isothiocyanate (556-61-6), (15.31) metrafenone (220899-03-6), (15.32) mildiomycin (67527-71-3), (15.33) natamycin (7681-93-8), (15.34) nickel dimethyldithiocarbamate (15521-65-0), (15.35) nitrothal-isopropyl (10552-74-6), (15.36) octhilinone (26530-20-1), (15.37) oxamocarb (917242-12-7), (15.38) oxyfenthiin (34407-87-9), (15.39) pentachlorophenol and salts (87-86-5), (15.40) phenothrin, (15.41) phosphorous acid and its salts (13598-36-2), (15.42) propamocarb-fosetylate, (15.43) propanosine-sodium (88498-02-6), (15.44) proquinazid (189278-12-4), (15.45) pyrimorph (868390-90-3), (15.45e) (2E)-3-(4-tert-butylphenyl)-3-(2-chloropyridin-4-yl)-1-(morpholin-4-yl)prop-2-en-1-one (1231776-28-5), (15.45z) (2Z)-3-(4-tert-butylphenyl)-3-(2-chloropyridin-4-yl)-1-(morpholin-4-yl)prop-2-en-1-one (1231776-29-6), (15.46) pyrrolnitrine (1018-71-9) (EP-A 1 559 320), (15.47) tebufloquin (376645-78-2), (15.48) tecloftalam (76280-91-6), (15.49) tolnifanide (304911-98-6), (15.50) triazoxide (72459-58-6), (15.51) trichlamide (70193-21-4), (15.52) zarilamid (84527-51-5), (15.53) (3S,6S,7R,8R)-8-benzyl-3-[({3-[(isobutyryloxy)methoxy]-4-methoxypyridin-2-yl}carbonyl)amino]-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl2-methylpropanoate (517875-34-2) (WO2003035617), (15.54) 1-(4-{4-[(5R)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (1003319-79-6) (WO 2008013622), (15.55) 1-(4-{4-[(5S)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (1003319-80-9) (WO 2008013622), (15.56) 1-(4-{4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (1003318-67-9) (WO 2008013622), (15.57) 1-(4-methoxyphenoxy)-3,3-dimethylbutan-2-yl 1H-imidazole-1-carboxylate (111227-17-9), (15.58) 2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine (13108-52-6), (15.59) 2,3-dibutyl-6-chlorothieno[2,3-d]pyrimidin-4(3H)-one (221451-58-7), (15.60) 2,6-dimethyl-1H,5H-[1,4]dithiino[2,3-c:5,6-c′]dipyrrole-1,3,5,7(2H,6H)-tetrone, (15.61) 2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[(5R)-5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone (1003316-53-7) (WO 2008013622), (15.62) 245-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[(5S)-5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone (1003316-54-8) (WO 2008013622), (15.63) 2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-(5-phenyl-4,5-dihydro-1,2-oxazol-3-yl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone (1003316-51-5) (WO 2008013622), (15.64) 2-butoxy-6-iodo-3-propyl-4H-chromen-4-one, (15.65) 2-chloro-5-[2-chloro-1-(2,6-difluoro-4-methoxyphenyl)-4-methyl-1H-imidazol-5-yl]pyridine, (15.66) 2-phenylphenol and salts (90-43-7), (15.67)3-(4,4,5-trifluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline (861647-85-0) (WO2005070917), (15.68) 3,4,5-trichloropyridine-2,6-dicarbonitrile (17824-85-0), (15.69) 3-[5-(4-chlorophenyl)-2,3-dimethyl-1,2-oxazolidin-3-yl]pyridine, (15.70) 3-chloro-5-(4-chlorophenyl)-4-(2,6-difluorophenyl)-6-methylpyridazine, (15.71) 4-(4-chlorophenyl)-5-(2,6-difluorophenyl)-3,6-dimethylpyridazine, (15.72) 5-amino-1,3,4-thiadiazole-2-thiol, (15.73) 5-chloro-N′-phenyl-N′-(prop-2-yn-1-yl)thiophene-2-sulfonohydrazide (134-31-6), (15.74) 5-fluoro-2-[(4-fluorobenzyl)oxy]pyrimidin-4-amine (1174376-11-4) (W02009094442), (15.75) 5-fluoro-2-[(4-methylbenzyl)oxy]pyrimidin-4-amine (1174376-25-0) (WO2009094442), (15.76) 5-methyl-6-octyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, (15.77) ethyl (2Z)-3-amino-2-cyano-3-phenylprop-2-enoate, (15.78) N′-(4-{[3-(4-chlorobenzyl)-1,2,4-thiadiazol-5-yl]oxy}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide, (15.79) N-(4-chlorobenzyl)-3-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]propanamide, (15.80) N-[(4-chlorophenyl)(cyano)methyl]-3-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]propanamide, (15.81) N-[(5-bromo-3-chloropyridin-2-yl)methyl]-2,4-dichloropyridine-3-carboxamide, (15.82) N-[1-(5-bromo-3-chloropyridin-2-yl)ethyl]-2,4-dichloropyridine-3-carboxamide, (15.83) N-[1-(5-bromo-3-chloropyridin-2-yl)ethyl]-2-fluoro-4-iodopyridine-3-carboxamide, (15.84) N-{(E)-[(cyclopropylmethoxy)imino] [6-(difluoromethoxy)-2,3-difluorophenyl]methyl)-2-phenylacetamide (221201-92-9), (15.85) N-{(Z)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-difluorophenyl]methyl)-2-Phenylacetamide (221201-92-9), (15.86) N′-{4-[(3-tert-butyl-4-cyano-1,2-thiazol-5-yl)oxy]-2-chloro-5-methylphenyl}-N-ethyl-N-methylimidoformamide, (15.87) N-methyl-2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,3-thiazole-4-carboxamide (922514-49-6) (WO 2007014290), (15.88) N-methyl-2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1,3-thiazole-4-carboxamide (922514-07-6) (WO 2007014290), (15.89) N-methyl-2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-N-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]-1,3-thiazole-4-carboxamide (922514-48-5) (WO 2007014290), (15.90) pentyl {6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylidene]amino}oxy)methyl]pyridin-2-yl}carbamate, (15.91) phenazine-1-carboxylic acid, (15.92) quinolin-8-ol (134-31-6), (15.93) quinolin-8-ol sulfate (2:1) (134-31-6) and (15.94) tert-butyl {6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate.

(16) Further compounds, for example (16.1) 1-methyl-3-(trifluoromethyl)-N[2′-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide, (16.2) N-(4′-chlorobiphenyl-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (16.3) N-(2′,4′-dichlorobiphenyl-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (16.4) 3-(difluoromethyl)-1-methyl-N-[4′-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide, (16.5) N-(2′,5′-difluorobiphenyl-2-yl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, (16.6) 3-(difluoromethyl)-1-methyl-N-[4′-(prop-1-yn-1-yl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.7) 5-fluoro-1,3-dimethyl-N-[4′-(prop-1-yn-1-yl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.8) 2-chloro-N44′-(prop-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (16.9) 3-(difluoromethyl)-N-[4′-(3,3-dimethylbut-1-yn-1-Abiphenyl-2-yl]-1-methyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.10) N-[4′-(3,3-dimethylbut-1-yn-1-yl)biphenyl-2-yl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.11) 3-(difluoromethyl)-N-(4′-ethynylbiphenyl-2-yl)-1-methyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.12) N-(4′-ethynylbiphenyl-2-yl)-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.13) 2-chloro-N-(4′-ethynylbiphenyl-2-yl)pyridine-3-carboxamide (known from WO 2004/058723), (16.14) 2-chloro-N-[4′-(3,3-dimethylbut-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (16.15) 4-(difluoromethyl)-2-methyl-N-[4′-(trifluoromethyl)biphenyl-2-yl]-1,3-thiazole-5-carboxamide (known from WO 2004/058723), (16.16) 5-fluoro-N-[4′-(3-hydroxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.17) 2-chloro-N14′-(3-hydroxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (16.18) 3-(difluoromethyl)-N-[4′-(3-methoxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]-1-methyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.19) 5-fluoro-N-[4′-(3-methoxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.20) 2-chloro-N-[4′-(3-methoxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (16.21) (5-bromo-2-methoxy-4-methylpyridin-3-yl)(2,3,4-trimethoxy-6-methylphenyl)methanone (known from EP-A 1 559 320), (16.22) N-[2-(4-{[3-(4-chlorophenyl)prop-2-yn-1-yl]oxy}-3-methoxyphenyl)ethyl]-N2-(methylsulfonyl)valinamide (220706-93-4), (16.23) 4-oxo-4-[(2-phenylethyl)amino]butanoic acid and (16.24) but-3-yn-1-yl {6-[({[(Z)-(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate.

All named mixing partners of the classes (1) to (16) can, if their functional groups enable this, optionally form salts with suitable bases or acids.

For the different aspects of the composition according to the invention, insecticide compound D is preferably selected in the list consisting of:

-   (1) Acetylcholinesterase (AChE) inhibitors, for example

carbamates, e.g. alanycarb, aldicarb, bendiocarb, benfuracarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobucarb, formetanate, furathiocarb, isoprocarb, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, propoxur, thiodicarb, thio-fanox, triazamate, trimethacarb, XMC, and xylylcarb; or

organophosphates, e.g. acephate, azarnethiphos, azinphos (-methyl, -ethyl), cadusafos, chlorethoxyfos, chlorfenvinphos, chlorfenvinphos, chlormephos, chlorpyrifos (-methyl), coumaphos, cyanophos, demeton-S-methyl, diazinon, dichlorvos/DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, famphur, fenamiphos, fenitrothion, fenthion, fosthiazate, heptenophos, isofenphos, isopropyl O-(methoxyaminothio-phosphoryl)salicylate, isoxathion, malathion, mecarbam, methamidophos, methidathion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion(-methyl), phenthoate, phorate, phosalone, phosmet, phosphamidon, phoxim, pirimiphos(-methyl), profenofos, propetamphos, prothiofos, pyraclofos, pyridaphenthion, quinalphos, sulfotep, tebupirirnfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, triclorfon, and vamidothion.

-   (2) GABA-gated chloride channel antagonists, for example

organochlorines, e.g. chlordane, endosulfan (alpha-); or fiproles (phenylpyrazoles), e.g. ethiprole, fipronil, pyrafluprole, and pyriprole.

-   (3) Sodium channel modulators/voltage-dependent sodium channel     blockers, for example pyrethroids, e.g. acrinathrin, allethrin     (d-cis-trans, d-trans), bifenthrin, bioallethrin, bioallethrin     S-cyclopentenyl, bioresmethrin, cycloprothrin, cyfluthrin (beta:),     cyhalothrin (gamma-,lambda-), cypermethrin (alpha-, beta-, theta-,     zeta-), cyphenothrin [(1R)-trans-isomers], deltamethrin,     dimefluthrin, empenthrin [(EZ)-(1 R)-isomers), esfenvalerate,     etofenprox, fenpropathrin, fenvalerate, flucythrinate, flumethrin,     fluvalinate (tau-), halfenprox, imiprothrin, nietofluthrin,     permethrin, phenothrin [(1R)-trans-isomer), prallethrin,     profluthrin, pyrethrin (pyrethrum), resmethrin, RU 15525,     silafluofen, tefluthrin, tetramethrin [(1R)- isomers)],     tralomethrin, transfluthrin and ZXI 8901; or

DDT; or methoxychlor.

-   (4) Nicotinergic acetylcholine receptor agonists, for example

chloronicotinyls, e.g. acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam,; or nicotine.

-   (5) Allosteric acetylcholine receptor modulators (agonists), for     example spinosyns, e.g. spinetoram and spinosad. -   (6) Chloride channel activators, for example     avermectins/milbemycins, e.g. abamectin, emamectin benzoate,     lepimectin, and milbemectin. -   (7) Juvenile hormone mimics, e.g. hydroprene, kinoprene, methoprene;     or fenoxycarb; pyriproxyfen. -   (8) Miscellaneous non-specific (multi-site) inhibitors, for example     gassing agents, e.g. methyl bromide and other alkyl halides; or     chloropicrin; sulfuryl fluoride; borax; tartar emetic. -   (9) Selective homopteran feeding, blockers, e.g. pymetrozine; or     flonicamid. -   (10) Mite growth inhibitors, e.g. clofentezine, diflovidazin,     hexythiazox, etoxazole. -   (11) Microbial disruptors of insect midgut membranes, e.g. Bacillus     thuringiensis subspecies israelensis, Bacillus sphaericus, Bacillus     thuringiensis subspecies aizawai, Bacillus thuringiensis subspecies     kurstaki, Bacillus thuringiensis subspecies tenebrionis, and BT crop     proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb,     Cry34/35Ab1.

(12) Inhibitors of mitochondrial ATP synthase, for example diafenthiuron; or

organotin miticides, e.g. azocyclotin, cyhexatin, and fenbutatin oxide; or

propargite; tetradifon.

(13) Uncouplers of oxidative phoshorylation via disruption of the proton gradient, for example chlorfenapyr, and DNOC.

-   (14) Nicotinic acetylcholine receptor channel blockers, for example     bensultap, cartap hydrochloride, thiocyclam, and thiosultap-sodium. -   (15) Inhibitors of chitin biosynthesis, type 0, for example     benzoylureas, e.g. bistrifluron, chlorfluazuron, diflubenzuron,     flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron,     noviflumuron, penfluron, teflubenzuron, and triflumuron. -   (16) Inhibitors of chitin biosynthesis, type 1, for example     buprofezin. -   (17) Moulting disruptors, for example cyromazine. -   (18) Ecdysone receptor agonists/disruptors, for example

diacylhydrazines, e.g. chromafenozide, halofenozide, methoxyfenozide, and tebufenozide.

-   (19) Octopamine receptor agonists, for example amitraz. -   (20) Mitochondria complex III electron transport inhibitors     (Coupling site II), for example hydramethylnon; acequinocyl;     fluacrypyrim; or cyflumetofen and cyenopyrafen.

(21) Mitochondrial complex I electron transport inhibitors, for example

METI acaricides, e.g. fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad;

or rotenone. (Derris).

-   (22) Voltage-dependent sodium channel blockers, e.g. indoxacarb;     metaflumizone. -   (23) Inhibitors of acetyl CoA carboxylase, for example tetronic acid     derivatives, e.g. spirodiclofen and spiromesifen; or

tetramic acid derivatives, e.g. spirotetramat.

-   (24) Mitochondrial complex IV electron inhibitors, for example     phosphines, e.g. aluminium phosphide, calcium phosphide, phosphine,     and zinc phosphide;

or cyanide.

-   (28) Ryanodine receptor modulators, for example diamides, e.g.     chlorantraniliprole (Rynaxypyr), Cyantraniliprole (Cyazypyr), and     flubendiamide.

Further active ingredients with unknown or uncertain mode of action, for example azadirachtin, amidoflumet, benzoximate, bifenazate, chinomethionat, cryolite, dicofol, flufenerim, pyridalyl, and pyrifluquinazon; or one of the following known active compounds

4-{[(6-brompyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115644), 4-{[(6-fluorpyrid-3-yl)methyl](2,2-difluorethyl)amino}furan-2(5H)-on (known from WO 2007/115644), 4-{[(2-chlor-1,3-thiazol-5-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115644), 4-{[(6-chlorpyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/ 115644), 4-{[(6-chlorpyrid-3-yl)methyl](2,2-difluorethyl)amino}furan-2(5H)-on known from WO 2007/115644), 4-{[(6-chlor-5-fluorpyrid-3-yl)methyl](methyl)amino}furan-2(5H)-on (known from WO 2007/115643), 4-{[(5,6-dichlorpyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115646), 4-{[(6-chlor-5-fluorpyrid-3-yl)methyl]cyclopropyl)amino}furan-2(5H)-on (known, from WO 2007/115643), 4-{[(6-chlorpyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-on (known from EP-A-0 539 588), 4-{[(6-chlorpyrid-3-yl)methyl](methyl)amino}furan-2(5H)-on (known from EP-A-0 539 588), [(6-chlorpyridin-3-yl)methyl](methyl)oxido-λ⁴-sulfanylidencyanamid (known from WO 2007/149134), [1-(6-chlorpyridin-3-yl)ethyl](methyl)oxido-λ⁴-sulfanylidencyanamid (known from WO 2007/149134) and its diastereomeres (A) and (B)

(also known from WO 2007/149134), [(6-trifluormethylpyridin-3-yl)methyl]methyl)oxido-λ⁴-sulfanylidencyanamid (known from WO 2007/095229), or sulfoxaflor (also known from WO 2007/149134),

11-(4-chloro-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one

(known from WO 2006/089633), 3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one (known from WO 2008/067911), and 1-{2,4-dimethyl-5-[(2,2,2-trifluoroethyl)sulfinyl]phenyl}-3-(trifluoromethyl)-1H-1,2,4-triazole (known from WO 1999/55668).

The active ingredients specified in this description by their “common name” are known, for example, from “The Pesticide Manual”, 14th Ed., British Crop Protection Council 2006, and from the Web page http://www.alanwood.net/pesticides.

For the various aspects of the composition according to the invention, more preferred insecticide compounds are selected in the list consisting of imidacloprid and clothianidin.

For the composition according to the invention, the NB weight ratio preferably ranges from 1/0.01 to 1/100; more preferably from 1/0.05 to 1/80.

For the composition according to the invention, the A/B/C or A/B/D weight ratio preferably ranges from 1/0.01/0.01 to 1/100/100; more preferably from 1/0.05/0.05 to 1/80/80. For the composition according to the invention, the A/B/C/D weight ratio preferably ranges from 1/0.01/0.01/0.1 to 1/100/100/100; more preferably from 1/0.05/0.05/0.5 to 1/80/80/80.

Particular compositions according to the invention are defined as combining all or part of:

-   -   preferred oxime compounds of formula (I) as herein-defined;     -   referred thiazolylpiperidine derivative of formula (II) as         herein-defined;     -   preferred fungicide compounds C;     -   preferred insecticide compounds D;     -   preferred weight ratios of active substances.

According to another aspect of the present invention, in the pesticide composition according to the invention, the compound ratio A/B can be advantageously selected so as to produce a synergistic effect. The term synergistic effect is understood to mean in particular that defined by Colby in an article entitled “Calculation of the synergistic and antagonistic responses of herbicide combinations” Weeds, (1967), 15, pages 20-22.

The latter article mentions the formula:

$E = {X + Y - \frac{X\; Y}{100}}$ wherein E represents the expected percentage of inhibition of the pest for the combination of the two compounds at defined doses (for example equal to x and y respectively), X is the percentage of inhibition observed, for the pest by compound A at a defined dose (equal to x), Y is the percentage of inhibition observed for the pest by, compound B at a defined dose (equal to y). When the percentage of inhibition observed for the combination is greater than E, there is a synergistic effect.

The term “synergistic effect” also means the effect defined by application of the Tammes method, “Isoboles, a graphic representation of synergism in pesticides”, Netherlands Journal of Plant Pathology, 70(1964), pages 73-80.

According to another aspect of the present invention, in the pesticide composition according to the invention, the compound ratio A/B/C can be advantageously selected so as to produce a synergistic effect. The term synergistic effect is understood to mean in particular that defined by Colby in an article entitled “Calculation of the synergistic and antagonistic responses of herbicide combinations” Weeds, (1967), 15, pages 20-22.

The latter article mentions the formula:

$E = {X + Y + Z - \frac{X\; Y\; Z}{100}}$ wherein E represents the expected percentage of inhibition of the pest for the combination of the three compounds at defined doses (for example equal to x, y and z respectively), X is the percentage of inhibition observed for the pest by compound A at a defined dose (equal to, x), Y is the percentage of inhibition observed for the pest by compound B at a defined dose (equal to y) and Z is the percentage of inhibition observed for the pest by, compound C at a defined dose (equal to z). When the percentage of inhibition observed for the combination is greater than E, there is a synergistic effect.

The term “synergistic effect” also means the effect, defined by, application of the Tammes to method, “Isoboles, a graphic representation of synergism in pesticides”, Netherlands Journal of Plant Pathology, 70(1964), pages 73-80.

Synergistic compositions comprising further active substances also form part of the present invention, the associated synergistic effect can be evidenced in a similar manner.

The pesticide composition according to the invention may comprise from 0.00001 to 100%, preferably from 0.001 to 80%, of active compounds, whether these compounds are combined or whether they are in, the form of two or more active ingredients used separately.

More generally, the pesticide composition according to the invention may eventually also comprise one or more other active substances selected from fungicide, herbicide, insecticide or plant growth regulator active compounds.

In addition to these additional active agents, the pesticide composition according to the invention, may also comprise, any other adjuvants or auxiliary agent useful in plant protection formulations such as, for example, an, agriculturally suitable inert carrier and optionally, an agriculturally suitable surfactant.

For its practical use, the pesticide composition according to the invention can be used alone or in formulations containing, one or the other of the active ingredients or alternatively both of them together, in combination or association with one or, more other compatible components which are, for example, solid or liquid fillers or diluents, adjuvants, surfactants or equivalents, which are suitable for the desired use and which are acceptable for uses in agriculture. The formulations can be of any type known in the sector that is suitable for application onto all types of cultures or, crops. These, formulations, which can be prepared in any manner known by, the skilled person, also form part of the invention.

The formulations may also contain ingredients of other types, such as protective colloids, adhesives, thickeners, thixotropic agents, penetrating agents, oils for, spraying, stabilisers, preserving agents (in particular mould-proofing or biocide agents), sequestering or chelating agents or the like. More generally, the compounds used in the invention can be combined with any solid or liquid additives corresponding to the usual formulation techniques.

The term “filler” means an organic or inorganic, natural or synthetic component with which the active components are combined to facilitate its application, for example, onto the plants, the seeds or the soil. This filler is consequently generally inert and it must be acceptable (for example acceptable for agronomic uses, in particular for treating plants).

The filler can be solid, for example clays, natural or synthetic silicates, silica, resins, waxes, solid fertilizers (for example ammonium salts), natural soil minerals, such as kaolins, clays, talc, lime, quartz, attapulgite, montmorillonite, bentonite or diatomaceous earths or synthetic minerals, such as silica, alumina or silicates, in particular aluminium or magnesium silicates.

The solid fillers which are suitable for granules are as follows: natural, crushed or broken rocks, such as calcite, marble, pumice, sepiolite and dolomite; synthetic granules of inorganic or organic flours; granules of organic material such as sawdust, coconut shell, corn ear or envelope or tobacco stem; kieselguhr, tricalcium phosphate, powdered cork or adsorbent carbon black; water-soluble polymers, resins, waxes; or solid fertilizers. Such composition may, if so desired, contain one or more compatible agents such as wetting agents, dispersing agents, emulsifiers or colourings which, when they are solid, may also act as diluents.

The fillers may also be liquid, for example: water, alcohols, in particular butanol or glycol, as well as ethers or esters thereof, in particular methyl glycol acetate; ketones, in particular acetone, cyclohexanone, methyl ethyl ketone, methyl isobutyl ketone or isophorone; petroleum fractions such as paraffinic or aromatic hydrocarbons, in particular xylenes or alkylnaphthalenes; mineral or plant oils; aliphatic chlorohydrocarbons, in particular trichloroethane or methylene chloride; aromatic chlorohydrocarbons, in particular chlorobenzenes; water-soluble or highly polar solvents such as dimethylformamide, dimethyl sulfoxide, N,N-dimethyl-acetamide or N-methylpyrrolidone; N-octylpyrrolidone, liquefied gases; or the like, whether they are taken separately or as a mixture.

The surfactant can be an emulsifier, a dispersing agent or a wetting agent, of ionic or nonionic type or a mixture of these surfactants. Among those surfactants there are used, for example, polyacrylic acid salts, lignosulfonic acid salts, phenolsulfonic or naphthalenesulfonic acid salts, polycondensates of ethylene oxide with fatty alcohols or fatty acids or fatty esters or fatty amines, substituted phenols (in particular alkylphenols or arylphenols), ester-salts of sulfosuccinic acid, taurine derivatives (in particular alkyl taurates), phosphoric esters of alcohols or of polycondensates of ethylene oxide with phenols, fatty acid esters with polyols or sulfate, sulfonate or phosphate functional derivatives of the compounds described above. The presence of at least one surfactant is generally essential when the active ingredients and/or the inert filler are, insoluble or only sparingly soluble in water, and when the filler for the said composition to be applied is water.

The formulations may also contain other additives such as adhesives or dyes. Adhesives such as carboxymethylcellulose or natural or synthetic polymers in the form of powders, granules or matrices, such as gum arabic, latex, polyvinylpyrrolidone, polyvinyl alcohol or polyvinyl acetate, natural phospholipids, such as cephalins or lecithins or synthetic phospholipids can be used in the, formulations. It is possible to use colourings such as inorganic, pigments, such as, for example: iron oxides, titanium oxides, Prussian blue; organic colouring stuffs, such as those of the alizarin, azo or metal phthalocyanin type; or of trace elements such as iron, manganese, boron, copper, cobalt, molybdenum or zinc salts.

The form of the pesticide composition according to the invention can, be selected in a large number of formulations, such as aerosol dispenser; suspension of, capsules; cold fogging concentrate; dustable powder; emulsifiable concentrate; aqueous/aqueous type emulsion; oil/inverse type emulsion; encapsulated granule; fine granule; suspension concentrate for seed treatment; compressed gas; gas generating product; granule; hot fogging concentrate; macrogranule; microgranule; oil-dispersible powder; oil miscible suspension concentrate; oil-miscible liquid; paste; plant rodlet; powder for dry seed treatment; seeds, coated with a pesticide; smoke maydle; smoke cartridge; smoke generator; smoke, pellet; smoke, rodlet; smoke tablet; smoke tin; soluble concentrate; soluble powder; solution for seed treatment; suspension concentrate (=flowable concentrate); ultra low volume liquid; ultra low volume suspension; vapour releasing product; water-dispersible granules or tablets; water dispersible powder for slurry treatment; water-soluble granules or tablets; water-soluble powder for seed treatment; wettable powder.

The pesticide composition according to the present invention covers not only the compositions which are ready to be applied to the crop by means of a suitable device, such as a spraying device, but also the commercial concentrated composition which have to be diluted before application to the crop.

The pesticide composition herein described is used in general for application to growing plants or to sites where crops are grown or intended to grow or, for the treatment, coating or film-coating of seeds.

According to the present invention, seeds may comprise any propagation materials, like for example seeds, fruit, tubers, grains, roots, rhizomes, parts of plants.

The pesticide composition according to the invention may also be applied to the vegetation and in particular to the leaves infested or capable of being infested with the phytopathogenic fungi or damaged by insects. Another method of applying the pesticide composition according to the invention is to add a formulation containing the active ingredients to the irrigation water.

According to another object of the present invention, there is provided a method for controlling the phytopathogenic fungi or damaging insects of plants, crops or seeds, characterized in that an agronomically effective and substantially non-phytotoxic quantity of a pesticide composition according to the invention is applied as seed treatment, foliar application, stem application, drench or drip application (chemigation) to the seed, the plant or to the fruit of the plant or to soil or to inert substrate (e.g. inorganic substrates like sand, rockwool, glasswool; expanded minerals like perlite, vermiculite, zeolite or expanded clay), Pumice, Pyroclastic materials or stuff, synthetic organic substrates (e.g. polyurethane) organic substrates (e.g. peat, composts, tree waste products like coir, wood fibre or chips, tree bark) or to a liquid substrate (e.g. floating hydroponic systems, Nutrient Film Technique, Aeroponics) wherein the plant is growing or wherein it is desired to grow.

The expression “are applied to the plants to be treated” is understood to mean, for the purposes of the present invention, that the pesticide composition which is the subject of the invention can be applied by means of various methods of treatment such as:

-   -   spraying onto the aerial parts of the said plants a liquid         comprising one of the said compositions,     -   dusting, the incorporation into the soil of granules or powders,         spraying, around the said plants, and in the case of trees         injection or daubing,     -   coating or film-coating the seeds of the said plants with the         aid of a plant-protection mixture comprising one of the said         compositions.

The method according to the invention may either be a curing, preventing or eradicating method.

In this method, a composition used can be prepared beforehand by mixing the two or more active compounds according to the invention.

According to an alternative of such a method, it is also possible to apply simultaneously, successively or separately compounds (A), (B), (C) or (D) so as to have the conjugated (A)/(B)/(C)/(D) effects, of distinct compositions each containing one or more active ingredients (A), (B), (C) or (D).

The dose of active compound usually, applied in the method of treatment according to the invention is generally and, advantageously

-   -   for foliar treatments: from 0.1 to 10,000 g/ha, preferably from         10 to 1,000 g/ha, more preferably from 50 to 300g/ha; in case of         drench or drip application, the dose can even be, reduced,         especially while using inert substrates like rockwool or         perlite;     -   for seed treatment: from 2 to 200 g per 100 kilogram of seed,         preferably from 3 to 150 g per 100 kilogram of seed;     -   for soil treatment: from 0.1 to 10,000 g/ha, preferably from 1         to 5,000 g/ha.

The doses herein indicated are given as illustrative Examples of method according to the invention. A person skilled in the art will know how to adapt the application doses, notably according to the nature of the plant or crop to be treated.

Under specific conditions, for example according to the nature of the phytopathogenic fungus to be treated or insect to control, a lower dose may offer adequate protection. Certain climatic conditions, resistance or other factors like the nature of the phytopathogenic fungi or damaging insect to be eliminated or the degree of infestation, for example, of the plants with these fungi, may require higher doses of combined active ingredients.

The optimum dose usually depends on, several factors, for example on the type of phytopathogenic fungus to be treated or insect to control, on the type or level of development of the infested plant, on the density of vegetation or alternatively on the method of application.

Without it being limiting, the crop, treated with the pesticide composition or combination according to the invention is, for example, grapevine, but this could be cereals vegetables, lucerne, soybean, market garden crops, turf, wood, tree or horticultural plants.

The method of treatment according to the invention may also be useful to treat propagation material such as tubers or rhizomes, but also seeds, seedlings or seedlings pricking out and plants or plants pricking out. This method of treatment may also be useful to treat roots. The method of treatment according to the invention may also be useful to treat the over-ground parts of the plant such as trunks, stems or stalks, leaves, flowers and fruit of the concerned plant.

Among the plants that may becan be protected by the method according to the invention, mention may becan be made of cotton; flax; vine; fruit or vegetable crops such as Rosaceae sp. (for instance pip fruit such as apples and pears, but also stone fruit such as apricots, almonds and peaches), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for instance banana trees and plantins), Rubiaceae sp., Theaceae sp., Sterculiceae sp., Rutaceae sp. (for instance lemons oranges and grapefruit); Solanaceae sp. (for instance tomatoes), Liliaceae sp., Asteraceae sp. (for instance lettuces), Umbelliferae sp., Cruciferae sp., Chenopodiaceae sp., Cucurbitaceae sp., Papilionaceae sp. (for instance peas), Rosaceae sp. (for instance strawberries); major crops such as Graminae sp. (for instance maize, lawn or cereals such as wheat, rye, rice, barley and triticale), Asteraceae sp. (for instance sunflower), Cruciferae sp. (for instance colza), Fabacae sp. (for instance peanuts), Papilionaceae sp. (for instance soybean), Solanaceae sp. (for instance potatoes), Chenopodiaceae sp. (for instance beetroots), Elaeis sp. (for instance oil palm); horticultural and forest crops; as well as genetically modified homologues of these crops.

According to the invention all plants and plant parts can be treated. By plants is meant all plants and plant populations such as desirable and undesirable wild plants, cultivars and plant varieties (whether or not protectable by plant variety or plant breeder's rights). Cultivars and plant varieties can be plants obtained by conventional propagation and breeding methods is which can be assisted or supplemented by one or more biotechnological methods such as by use of double haploids, protoplast fusion, random and directed mutagenesis, molecular or genetic markers or by bioengineering and genetic engineering methods. By plant parts is meant all above ground and below ground parts and organs of plants such as shoot, leaf, blossom and root, whereby for example leaves, needles, stems, branches, blossoms, fruiting bodies, fruits and seed as well as roots, corms and rhizomes are listed. Crops and vegetative and generative propagating material, for example cuttings, corms, rhizomes, runners and seeds also belong to plant parts.

Among the plants that can be protected by the method according to the invention, mention may be made of major field crops like com, soybean, cotton, Brassica oilseeds such as Brassica napus (e.g. canola), Brassica rapa, B. juncea (e.g. mustard) and Brassica catinata, rice, wheat, sugarbeet, sugarcane, oats, rye, barley, millet, triticale, flax, vine and various fruits and vegetables of various botanical taxa such as Rosaceae sp. (for instance pip fruit such as apples and pears, but also stone fruit such as apricots, cherries, almonds and peaches, berry fruits such as strawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for instance banana trees and plantings), Rubiaceae sp. (for instance coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for instance lemons, oranges and grapefruit); Solanaceae sp. (for instance tomatoes, potatoes, peppers, eggplant), Liliaceae sp., Compositiae sp. (for instance lettuce, artichoke and chicory—including root chicory, endive or common chicory), Umbelliferae sp. (for instance carrot, parsley, celery and celeriac), Cucurbitaceae sp. (for instance cucumber—including pickling cucumber, squash, watermelon, gourds and melons), Alliaceae sp. (for instance onions and leek), Cruciferae sp. (for instance white cabbage, red, cabbage, broccoli, cauliflower, brussel sprouts, pak choi, kohlrabi, radish, horseradish, cress, Chinese cabbage), Leguminosae sp. (for instance peanuts, peas and beans beans—such as climbing beans and broad beans), Chenopodiaceae sp. (for instance mangold, spinach beet, spinach, beetroots), Malvaceae (for instance okra), Asparagaceae (for instance asparagus); horticultural and forest crops; ornamental plants; as well as genetically modified homologues of these crops.

The method of treatment according to the invention can be used in the treatment of genetically modified organisms (GMOs), e.g. plants or seeds. Genetically modified plants (ortransgenic plants) are plants of which a heterologous gene has been stably integrated into genome. The expression “heterologous gene” essentially means a gene, which is provided or assembled outside the plant and when introduced in the nuclear, chloroplastic or mitochondrial genome gives the transformed plant new or improved agronomic or other properties by expressing a protein or polypeptide of interest or by downregulating or silencing other gene(s) which are present in, the plant (using for example, antisense technology, cosuppression technology or RNA interference—RNAi-technology). A heterologous gene that is located in the genome is also called a transgene. A transgene that is defined by its particular location in the plant genome is called a transformation or transgenic event.

Depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vegetation period, diet), the treatment according to the invention may also result in superadditive (“synergistic”) effects. Thus, for example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the active compounds and compositions which can be used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, bigger fruits, larger plant height, greener leaf color, earlier flowering, higher quality and/or a higher nutritional value of the harvested products, higher sugar concentration within the fruits, better storage stability and/or processability of the harvested products are possible, which exceed the effects which were actually to be expected.

At certain application rates, the active compound combinations according to the invention may also have a strengthening effect in plants. Accordingly, they are also suitable for mobilizing the defense system of the plant against attack by unwanted microorganisms. This may if appropriate, be one of the reasons of the enhanced activity of the combinations according to the invention, for example against fungi. Plant-strengthening (resistance-inducing) substances are to be understood as meaning, in the present context, those substances or combinations of substances which are capable of stimulating the defense system of plants in such a way that, when subsequently inoculated with unwanted microorganisms, the treated plants display a substantial degree of resistance to these microorganisms. In the present case, unwanted microorganisms are to be understood as meaning phytopathogenic fungi, bacteria and viruses. Thus, the substances according to the invention can be employed for protecting plants against attack by the abovementioned pathogens within a certain period of time after the treatment. The period of time within which protection is effected generally extends from 1 to 10 days, preferably 1 to 7 days, after the treatment of the plants with the active compounds.

Plants and plant cultivars which are preferably to be treated according to the invention include all plants which have genetic material which impart particularly advantageous, useful traits to these plants (whether obtained by breeding and/or biotechnological means).

Plants and plant cultivars which are also preferably to be treated according to the invention are resistant against one or more biotic stresses, i.e. said plants show a better defense against animal and microbial pests, such as against nematodes, insects, mites, phytopathogenic fungi, bacteria, viruses and/or viroids.

Examples of nematode resistant plants are described in e.g. U.S. patent application Ser. Nos. 11/765,491, 11/765,494, 10/926,819, 10/782,020, 12/032,479, 10/783,417, 10/782,096, 11/657,964, 12/192,904, 11/396,808, 12/166,253, 12/166,239, 12/166,124, 12/166,209, 11/762,886, 12/364,335, 11/763,947, 12/252,453, 12/209,354, 12/491,396 or 12/497,221.

Plants and plant cultivars which may also be treated according to the invention are those plants which are resistant to one or more abiotic stresses. Abiotic stress conditions may include, for example, drought, cold temperature exposure, heat exposure, osmotic stress, flooding, increased soil salinity, increased mineral exposure, ozone exposure, high light exposure, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients, shade avoidance. Plants and plant cultivars which may also be treated according to the invention, are those plants characterized by enhanced yield characteristics. Increased yield in said plants can be the result of, for example, improved plant physiology, growth and development, such as water use efficiency, water retention efficiency, improved nitrogen use, enhanced carbon assimilation, improved photosynthesis, increased germination efficiency and accelerated maturation. Yield can furthermore be affected by improved plant architecture (under stress and non-stress conditions), including but not limited to, early flowering, flowering control for hybrid seed production, seedling vigor, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or ear number, seed number per pod or ear, seed mass, enhanced seed filling, reduced seed dispersal, reduced pod dehiscence and lodging resistance. Further yield traits include seed composition, such as carbohydrate content, protein content, oil content and composition, nutritional value, reduction in anti-nutritional compounds, improved processability and better storage stability.

Examples of plants with the above-mentioned traits are non-exhaustively listed in Table A.

Plants that may be treated according to, the invention are hybrid plants that already express the characteristic of heterosis or hybrid vigor which results in generally higher yield, vigor, health and resistance towards biotic and abiotic stresses). Such plants are typically made by crossing an inbred male-sterile parent line (the female parent) with another inbred male-fertile parent line (the male parent). Hybrid seed is typically harvested from the male sterile plants and sold to growers. Male sterile plants can, sometimes (e.g. in corn) be produced by detasseling, i.e. the mechanical removal of the male reproductive organs (or males flowers) but, more typically, male sterility is the result of genetic determinants in the plant genome. In that case, and especially when seed is the desired product to be harvested from the hybrid plants it is typically useful to ensure that male fertility in the hybrid plants is fully restored. This can be accomplished by ensuring that the male parents have appropriate fertility restorer genes, which are capable of restoring the male fertility in hybrid plants that contain the genetic determinants responsible for male-sterility. Genetic determinants for male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) were for instance described in Brassica species (WO 92/05251, WO 95/09910, WO 98/27806, WO 05/002324, WO 06/021972 and U.S. Pat. No. 6,229,072). However, genetic determinants for male sterility can also be located in the nuclear genome. Male sterile plants can also be obtained by plant biotechnology methods such as genetic engineering. A particularly useful means of obtaining male-sterile plants is described in WO 89/10396 in which, for example, a ribonuclease such as bamase is selectively, expressed in the tapetum cells in the stamens. Fertility, can then be restored by expression in the tapetum cells of a ribonuclease inhibitor such as barstar (e.g. WO 91/02069).

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may be treated according to the invention are herbicide-tolerant plants, i.e. plants made tolerant to one or more given herbicides. Such plants can be obtained either by genetic transformation, or by selection of plants containing a mutation imparting such herbicide tolerance.

Herbicide-resistant plants are for example glyphosate-tolerant plants, i.e. plants made tolerant to the herbicide glyphosate or salts thereof. Plants can be made tolerant to glyphosate through different means. For example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium (Comai et al., 1983, Science 221, 370-371), the CP4 gene of the bacterium Agrobacterium sp. (Barry et al., 1992, Curr. Topics Plant Physiol. 7, 139-145), the genes encoding a Petunia EPSPS (Shah et al., 1986, Science 233, 478-481), a Tomato EPSPS (Gasser et al., 1988, J. Biol. Chem. 263, 4280-4289), or an Eleusine EPSPS (WO 01/66704). It can also be a mutated EPSPS as described in for example EP 0837944, WO 00/66746, WO 00/66747 or WO02/26995. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate oxido-reductase enzyme as described in U.S. Pat. Nos. 5,776,760 and 5,463,175. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate acetyl transferase enzyme as described in for example WO 02/36782, WO 03/092360, WO 05/012515 and WO 07/024782. Glyphosate-tolerant plants can also be obtained by selecting plants containing naturally-occurring mutations of the above-mentioned genes, as described in for example WO 01/024615 or WO 03/013226. Plants expressing EPSPS genes that confer glyphosate tolerance are described in e.g. U.S. patent application Ser. Nos. 11/517,991, 10/739,610, 12/139,408, 12/352,532, 11/312,866, 11/315,678, 12/421,292, 11/400,598, 11/651,752, 11/681,285, 11/605,824, 12/468,205, 11/760,570, 11/762,526, 11/769,327, 11/769,255,>11/943801 or 12/362,774. Plants comprising other genes that confer glyphosate tolerance, such as decarboxylase genes, are described in e.g. U.S. patent, applications Ser. Nos. 11/588,811, 11/185,342, 12/364,724, 11/185,560 or 12/423,926.

Other herbicide resistant plants are for example plants that are made tolerant to herbicides inhibiting the enzyme glutamine synthase, such as bialaphos, phosphinothricin or glufosinate. Such plants can be obtained by expressing an enzyme detoxifying the herbicide or a mutant glutamine synthase enzyme that is resistant to inhibition, e.g. described in U.S. patent application Ser. No. 11/760,602. One such efficient detoxifying enzyme is an enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinothricin acetyltransferase are for example described in U.S. Pat. Nos. 5,561,236; 5,648,477; 5,646,024; 5,273,894; 5,637,489; 5,276,268; 5,739,082; 5,908,810 and 7,112,665.

Further herbicide-tolerant plants are also plants that are made tolerant to the herbicides inhibiting the enzyme hydroxyphenylpyruvatedioxygenase (HPPD).

Hydroxyphenylpyruvatedioxygenases are enzymes that catalyze the reaction in which para-hydroxyphenylpyruvate (HPP) is transformed into homogentisate. Plants tolerant to HPPD-inhibitors, can be transformed with a gene, encoding a naturally-occurring resistant HPPD enzyme, or a gene encoding a mutated or chimeric HPPD enzyme as described in WO 96/38567, WO 99/24585, WO 99/24586, WO 2009/144079, WO 2002/046387, or U.S. Pat. No. 6,768,044. Tolerance to HPPD-inhibitors can also be obtained by transforming plants with genes encoding certain enzymes enabling the formation of homogentisate despite the inhibition of the native HPPD enzyme by the HPPD-inhibitor. Such plants and genes are described in WO 99/34008 and WO 02/36787. Tolerance of plants to HPPD inhibitors can also be improved by transforming plants with a gene encoding an enzyme having prephenate deshydrogenase (PDH) activity in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO 2004/024928. Further, plants can be made more tolerant to HPPD-inhibitor herbicides by adding into their genome a gene encoding an enzyme capable of metabolizing or degrading HPPD inhibitors, such as the CYP450 enzymes shown in WO 2007/103567 and WO 2008/150473.

Still further herbicide resistant plants are plants that are made tolerant to acetolactate synthase (ALS) inhibitors. Known ALS-inhibitors include, for example, sulfonylurea, imidazolinone, triazolopyrimidines, pryimidinyoxy(thio)benzoates, and/or sulfonylaminocarbonyltriazolinone herbicides. Different mutations in the ALS enzyme (also known as acetohydroxyacid synthase, AHAS) are known to confer tolerance to different herbicides and groups of herbicides, as described for example in Tranel and Wright (2002, Weed Science 50:700-712), but also, in U.S. Pat. Nos. 5,605,011, 5,378,824, 5,141,870, and 5,013,659. The production of sulfonylurea-tolerant plants and imidazolinone-tolerant plants is described in U.S. Pat. Nos. 5,605,011; 5,013,659; 5,141,870; 5,767,361; 5,731,180; 5,304,732; 4,761,373; 5,331,107; 5,928,937; and 5,378,824; and international publication WO 96/33270. Other imidazolinone-tolerant plants are also described in for example WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373, WO 2006/015376, WO 2006/024351, and WO 2006/060634. Further sulfonylurea- and imidazolinone-tolerant plants are also described in for example WO 07/024782 and US Patent Application No 61/288958.

Other plants tolerant to imidazolinone and/or sulfonylurea can be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide or mutation breeding as described for example for soybeans in U.S. Pat. No. 5,084,082, for rice in WO 97/41218, for sugar beet in U.S. Pat. No. 5,773,702 and WO 99/057965, for lettuce in U.S. Pat. No. 5,198,599, or for sunflower in WO 01/065922.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are insect-resistant transgenic plants, i.e. plants made resistant to attack by certain target insects. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such insect resistance. An “insect-resistant transgenic plant”, as used herein, includes any plant containing at least one transgene comprising a coding sequence encoding:

-   -   1) an insecticidal crystal protein from Bacillus thuringiensis         or an insecticidal portion thereof, such as the insecticidal         crystal proteins listed by Crickmore et al. (1998, Microbiology         and Molecular Biology Reviews, 62: 807-813), updated by         Crickmore of al. (2005) at the Bacillus thuringiensis toxin         nomenclature, online at:         http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or         insecticidal portions thereof, e.g., proteins of the Cry protein         classes Cry1Ab, Cry1Ac, Cry1B, Cry1C, Cry1D, Cry1F, Cry2Ab,         Cry3Aa, or Cry3Bb or insecticidal portions thereof (e.g. EP         1999141 and WO 2007/107302), or such proteins encoded by         synthetic genes as e.g. described in and U.S. patent application         Ser. No. 12/249,016 ; or     -   2) a crystal protein from Bacillus thuringiensis or a portion         thereof which is insecticidal in the presence of a second other         crystal protein from Bacillus thuringiensis or a portion         thereof, such as the binary toxin made up of the Cry34 and Cry35         crystal proteins (Moellenbeck et al. 2001, Nat. Biotechnol. 19:         668-72; Schnepf et al. 2006, Applied Environm. Microbiol. 71,         1765-1774) or the binary toxin made up of the Cry1A or Cry1F         proteins and the Cry2Aa or Cry2Ab or Cry2Ae proteins (U.S.         patent application No. 12/214,022 and EP 08010791.5); or     -   3) a hybrid insecticidal protein comprising parts of different         insecticidal crystal proteins from Bacillus thuringiensis, such         as a hybrid of the proteins of 1) above or a hybrid of the         proteins of 2) above, e.g., the Cry1A.105 protein produced by         corn event MON89034 (WO 2007/027777); or     -   4) a protein of any one of 1) to 3) above wherein some,         particularly 1 to 10, amino acids have been replaced by another         amino acid to obtain a higher insecticidal activity to a target         insect species, and/or to expand the range of target insect         species affected, and/or because of changes introduced into the         encoding DNA during cloning or transformation, such as the         Cry3Bb1 protein in corn events MON863 or MON88017, or the Cry3A         protein in corn event MIR604; or     -   5) an insecticidal secreted protein from Bacillus thuringiensis         or Bacillus cereus, or an insecticidal portion thereof, such as         the vegetative insecticidal (VIP) proteins listed at:         http://www.lifesci.sussex.ac.uk/home/Neil Crickmore/Bt/vip.html,         e.g., proteins from the VIP3Aa protein class; or     -   6) a secreted protein from Bacillus thuringiensis or Bacillus         cereus which is insecticidal in the presence of a second         secreted protein from Bacillus thuringiensis or B. cereus, such         as the binary toxin made up of the VIP1A and VIP2A proteins (WO         94/21795); or     -   7) a hybrid, insecticidal protein comprising parts from         different secreted proteins from Bacillus thuringiensis or         Bacillus cereus, such as a hybrid of the proteins in 1) above or         a hybrid of the proteins in 2) above; or     -   8) a protein of any one of 5) to 7) above wherein some,         particularly 1 to 10, amino acids have been replaced by another         amino acid to obtain a higher insecticidal activity to a target         insect species, and/or to, expand the range of target insect         species affected, and/or because of changes introduced into, the         encoding DNA during, cloning or transformation (while still         encoding an insecticidal protein), such as the VIP3Aa protein in         cotton event COT102; or     -   9) a secreted protein from Bacillus thuringiensis or Bacillus         cereus which is insecticidal in the presence of a crystal         protein from Bacillus thuringiensis, such as the binary toxin         made up of VIP3 and Cry1A or Cry1F (U.S. Patent Appl. Nos.         61/126083 and 61/195019), or the binary toxin made up of the         VIP3 protein and the Cry2Aa or Cry2Ab or Cry2Ae proteins (U.S.         patent application Ser. No. 12/214,022 and. EP 08010791.5).     -   10) a protein of 9) above wherein some, particularly 1 to 10,         amino acids have been replaced by another amino acid, to obtain         a higher insecticidal activity to a target insect species,         and/or to expand the range of target insect species affected,         and/or because of changes introduced into the encoding DNA         during cloning or transformation (while still, encoding an         insecticidal protein)

Of course, an insect-resistant transgenic plant, as used herein, also includes any plant comprising a combination of genes encoding the proteins of any one of the above classes 1 to 10. In one embodiment, an insect-resistant plant contains more than one transgene encoding a protein of any one of the above classes 1 to 10, to expand the range of target insect species affected when using different proteins directed at different target insect species, or to delay insect resistance development to the plants by using different proteins insecticidal to the same target insect species but having a different mode of action, such as binding to different receptor binding sites in the insect.

An “insect-resistant transgenic plant”, as used herein, further includes any plant containing at least one transgene comprising a sequence producing upon expression a double-stranded RNA which upon ingestion by a plant insect pest inhibits the growth of this insect pest, as described e.g. in WO 2007/080126, WO 2006/129204, WO 2007/074405, WO 2007/080127 and WO 2007/035650.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are tolerant to abiotic stresses. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such stress resistance. Particularly useful stress tolerance plants include:

-   -   1) plants which contain a transgene capable of reducing the         expression and/or the activity of poly(ADP-ribose) polymerase         (PARP) gene in the plant cells or plants as described in WO         00/04173, WO/2006/045633, EP 04077984.5, or EP 06009836.5.     -   2) plants which contain a stress tolerance enhancing transgene         capable of reducing the expression and/or the activity of the         PARG encoding genes of the plants or plants cells, as described         e.g. in WO 2004/090140.     -   3) plants which contain a stress tolerance enhancing transgene         coding for a plant-functional enzyme of the nicotineamide         adenine dinucleotide salvage synthesis pathway including         nicotinamidase, nicotinate phosphoribosyltransferase, nicotinic         acid mononucleotide adenyl transferase, nicotinamide adenine         dinucleotide synthetase or nicotine amide         phosphorybosyltransferase as described e.g. in EP 04077624.7, WO         2006/133827, PCT/EP07/002433, EP 1999263, or WO 2007/107326.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention show altered quantity, quality and/or storage-stability of the harvested product and/or altered properties of specific ingredients of the harvested product such as

-   -   1) transgenic plants which synthesize a modified starch, which         in its physical-chemical characteristics, in particular the         amylose content or the amylose/amylopectin ratio, the degree of         branching, the average chain length, the side chain         distribution, the viscosity behaviour, the gelling strength, the         starch grain size and/or the starch grain morphology, is changed         in comparison with the synthesised starch in wild type plant         cells or plants, so that this is better suited for special         applications. Said transgenic plants synthesizing a modified         starch are disclosed, for example, in EP 0571427, WO 95/04826,         EP 0719338, WO 96/15248, WO 96/19581, WO 96/27674, WO 97/11188,         WO 97/26362, WO 97/32985, WO 97/42328, WO 97/44472, WO 97/45545,         WO 98/27212, WO 98/40503, W099/58688, WO 99/58690, WO 99/58654,         WO 00/08184, WO 00/08185, WO 00/08175, WO 00/28052, WO 00/77229,         WO 01/12782, WO 01/12826, WO 02/101059, WO 03/071860, WO         2004/056999, WO 2005/030942, WO 2005/030941, WO 2005/095632, WO         2005/095617, WO 2005/095619, WO 2005/095618, WO 2005/123927, WO         2006/018319, WO 2006/103107, WO 2006/108702, WO 2007/009823, WO         00/22140, WO 2006/063862, WO 2006/072603, WO 02/034923, EP         06090134.5, EP 06090228.5, EP 06090227.7, EP 07090007.1, EP         07090009.7, WO 01/14569, WO 02/79410, WO, 03/33540, WO         2004/078983, WO 01/19975, WO 95/26407, WO 96/34968, WO 98/20145,         WO 99/12950, WO 99/66050, WO 99/53072, U.S. Pat. No. 6,734,341,         WO 00/11192, WO 98/22604, WO 98/32326, WO 01/98509, WO 01/98509,         WO 2005/002359, U.S. Pat. No. 5,824,790, U.S. Pat. No.         6,013,861, WO 94/04693, WO 94/09144, WO 94/11520, WO 95/35026,         WO 97/20936     -   2) transgenic plants which synthesize non starch carbohydrate         polymers or which synthesize non starch carbohydrate polymers         with altered properties in comparison to wild type plants         without genetic modification. Examples are plants producing         polyfructose, especially of the inulin and levan-type, as         disclosed in EP 0663956, WO 96/01904, WO 96/21023, WO 98/39460,         and WO 99/24593, plants producing alpha-1,4-glucans as disclosed         in WO 95/31553, US 2002031826, U.S. Pat. Nos. 6,284,479,         5,712,107, WO 97/47806, WO 97/47807, WO 97/47808 and WO         00/14249, plants producing alpha-1,6 branched alpha-1,4-glucans,         as disclosed, in WO 00/73422, plants producing alternan, as         disclosed in e.g. WO 00/47727, WO 00/73422, EP 06077301.7, U.S.         Pat. No. 5,908,975 and EP 0728213,     -   3) transgenic plants which produce hyaluronan, as, for example         disclosed in WO 2006/032538, WO 2007/039314, WO 2007/039315, WO         2007/039316, JP 2006304779, and WO 2005/012529.     -   4) transgenic plants or hybrid plants, such as onions with         characteristics such as ‘high soluble solids content’, ‘low         pungency’ (LP) and/or ‘long storage’ (LS), as described in U.S.         patent application Ser. No. 12/020,360 and 61/054,026.

Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as cotton plants, with altered fiber characteristics. Such plants can be obtained by genetic transformation, or by selection of plants contain a mutation imparting such altered fiber characteristics and include:

-   -   a) Plants, such as cotton plants, containing an altered form of         cellulose synthase genes as described in WO 98/00549     -   b) Plants, such as cotton plants, containing an altered form of         rsw2 or rsw3 homologous nucleic acids as described in WO         2004/053219     -   c) Plants, such as cotton plants, with increased expression of         sucrose phosphate synthase as described in WO 01/17333     -   d) Plants, such as cotton plants, with increased expression of         sucrose synthase as described in WO 02/45485     -   e) Plants, such as cotton plants, wherein the timing of the         plasmodesmatal gating at the basis of the fiber cell is altered,         e.g. through downregulation of fiber-selective [3-1,3-glucanase         as described in WO 2005/017157, or as described in EP 08075514.3         or U.S. Patent Appl. No. 61/128,938     -   f) Plants, such as cotton plants, having fibers with altered         reactivity, e.g. through the expression of         N-acetylglucosaminetransferase gene including nodC and chitin         synthase genes as described in WO 2006/136351

Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered oil profile characteristics. Such plants can be obtained by genetic transformation, or by selection of plants contain a mutation imparting such altered oil profile characteristics and include:

-   -   a) Plants, such as oilseed rape plants, producing oil having a         high oleic acid content as described e.g. in U.S. Pat. Nos.         5,969,169, 5,840,946 or 6,323,392 or 6,063,947     -   b) Plants such as oilseed rape plants, producing oil having a         low linolenic acid content. as described in U.S. Pat. Nos.         6,270,828, 6,169,190, or 5,965,755     -   c) Plant such as oilseed rape plants, producing oil having a low         level of saturated fatty acids as described e.g. in U.S. Pat.         No. 5,434,283 or U.S. patent application Ser. No. 12/668,303

Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered seed shattering characteristics. Such plants can be obtained by genetic transformation, or by selection of plants contain a mutation imparting such altered seed shattering characteristics and include plants such as oilseed rape plants with delayed or reduced seed shattering as described in U.S. patent application No. 61/135,230 WO09/068313 and WO10/006732.

Particularly useful transgenic plants which may be treated according to the invention are plants containing transformation events, or combination of transformation events, that are the subject of petitions for non-regulated status, in the United States of America, to the Animal and Plant Health Inspection Service (APHIS) of the United States Department of Agriculture (USDA) whether such petitions are granted or are still pending. At any time this information is readily available from APHIS (4700 River Road Riverdale, Md. 20737, USA), for instance on, its internet site (URL http://www.aphis.usda.gov/brs/not_reg.html). On the filing date of this application the petitions for nonregulated status that were pending with APHIS or granted by APHIS were those listed in table B which contains the following information:

-   -   Petition: the identification number of the petition. Technical         descriptions of the transformation events can be found in the         individual petition documents which are obtainable from APHIS,         for example on the APHIS website, by reference to this petition         number. These descriptions are herein incorporated by reference.     -   Extension of Petition: reference to a previous petition for         which an extension is requested.     -   Institution: the name of the entity submitting the petition.     -   Regulated article: the plant species concerned.     -   Transgenic phenotype: the trait conferred to the plants by the         transformation event.     -   Transformation event or line: the name of the event or events         (sometimes also designated as lines or lines) for which         nonregulated status is requested.     -   APHIS documents: various documents published by APHIS in         relation to the Petition and which can be requested with APHIS.

Additional particularly useful plants containing single transformation events or combinations of transformation events are listed for example in the databases from various national or regional regulatory agencies (see for example http://gmoinfo.jrc.it/gmp_browse.aspx and http://www.agbios.com/dbase.php).

Further particularly transgenic plants include plants containing a transgene in an agronomically neutral or beneficial position as described in any of the patent publications listed in Table C.

TABLE A Trait Reference Water use efficiency WO 2000/073475 Nitrogen use efficiency WO 1995/009911 WO 2007/076115 WO 1997/030163 WO 2005/103270 WO 2007/092704 WO 2002/002776 Improved photosynthesis WO 2008/056915 WO 2004/101751 Nematode resistance WO 1995/020669 WO 2003/033651 WO 2001/051627 WO 1999/060141 WO 2008/139334 WO 1998/012335 WO 2008/095972 WO 1996/030517 WO 2006/085966 WO 1993/018170 Reduced pod dehiscence WO 2006/009649 WO 1997/013865 WO 2004/113542 WO 1996/030529 WO 1999/015680 WO 1994/023043 WO 1999/000502 Aphid resistance WO 2006/125065 WO 2008/067043 WO 1997/046080 WO 2004/072109 Sclerotinia resistance WO 2006/135717 WO 2005/000007 WO 2006/055851 WO 2002/099385 WO 2005/090578 WO 2002/061043 Botrytis resistance WO 2006/046861 WO 2002/085105 Bremia resistance US 20070022496 WO 2004/049786 WO 2000/063432 Erwinia resistance WO 2004/049786 Closterovirus resistance WO 2007/073167 WO 2002/022836 WO 2007/053015 Stress tolerance (including WO 2010/019838 WO2008/002480 drought tolerance) WO 2009/049110 WO2005/033318 Tobamovirus resistance WO 2006/038794

TABLE B Petitions of Nonregulated Status Granted or Pending by APHIS as of Mar. 31, 2010 Applicant Documents Extension of Petition Regulated Transgenic Transformation Petition Number *** Institution Article Phenotype Event or Line Petitions for Nonregulated Status Pending 10-070-01p Virginia Tech Peanut Sclerotinia blight N70, P39, and resistant W171 09-349-01p Dow Soybean Herbicide Tolerant DAS-68416-4 AgroSciences 09-328-01p Bayer Crop Soybean Herbicide Tolerant FG72 Science 09-233-01p Dow Corn Herbicide Tolerant DAS-40278-9 09-201-01p Monsanto Soybean MON-877Ø5-6 09-183-01p Monsanto Soybean MON-87769 09-082-01p Monsanto Soybean Lepidopteran resistant MON 87701 09-063-01p Stine Seed Corn Glyphosate tolerant HCEM485 09-055-01p Monsanto Corn Drought Tolerant MON 87460 09-015-01p BASF Plant Soybean Herbicide Tolerant BPS-CV127-9 Science, LLC Soybean 08-366-01p ArborGen Eucalyptus Freeze Tolerant, ARB-FTE1-08 Fertility Altered 08-340-01p Bayer Cotton Glufosinate Tolerant, T304-40XGHB119 Insect Resistant 08-338-01p Pioneer Corn Male Sterile, Fertility DP-32138-1 Restored, Visual Marker 08-315-01p Florigene Rose Altered Flower Color IFD-524Ø1-4 and IFD-529Ø1-9 07-253-01p Syngenta Corn Lepidopteran resistant MIR-162 Maize 07-108-01p Syngenta Cotton Lepidopteran Resistant COT67B 06-354-01p Pioneer Soybean High Oleic Acid DP-3Ø5423-1 05-280-01p Syngenta Corn Thermostable alpha- 3272 amylase 04-110-01p Monsanto & Alfalfa Glyphosate Tolerant J101, J163 Forage Genetics 03-104-01p Monsanto & Creeping Glyphosate Tolerant ASR368 Scotts bentgrass Petitions for Nonregulated Status Granted 07-152-01p Pioneer Corn glyphosate & DP-098140-6 Imidazolinone tolerant 04-337-01p University of Papaya Papaya Ringspot Virus X17-2 Florida Resistant 06-332-01p Bayer Cotton Glyphosate tolerant GHB614 CropScience 06-298-01p Monsanto Corn European Corn Borer MON 89034 resistant 06-271-01p Pioneer Soybean Glyphosate & 356043 acetolactate synthase (DP-356Ø43-5) tolerant 06-234-01p 98-329-01p Bayer Rice Phosphinothricin LLRICE601 CropScience tolerant 06-178-01p Monsanto Soybean Glyphosate tolerant MON 89788 04-362-01p Syngenta Corn Corn Rootworm MIR604 Protected 04-264-01p ARS Plum Plum Pox Virus C5 Resistant 04-229-01p Monsanto Corn High Lysine LY038 04-125-01p Monsanto Corn Corn Rootworm 88017 Resistant 04-086-01p Monsanto Cotton Glyphosate Tolerant MON 88913 03-353-01p Dow Corn Corn Rootworm 59122 Resistant 03-323-01p Monsanto Sugar Glyphosate Tolerant H7-1 Beet 03-181-01p 00-136-01p Dow Corn Lepidopteran Resistant TC-6275 & Phosphinothricin tolerant 03-155-01p Syngenta Cotton Lepidopteran Resistant COT 102 03-036-01p Mycogen/Dow Cotton Lepidopteran Resistant 281-24-236 03-036-02p Mycogen/Dow Cotton Lepidopteran Resistant 3006-210-23 02-042-01p Aventis Cotton Phosphinothericin LLCotton25 tolerant 01-324-01p 98-216-01p Monsanto Rapeseed Glyphosate tolerant RT200 01-206-01p 98-278-01p Aventis Rapeseed Phosphinothricin MS1 & RF1/RF2 tolerant & pollination control 01-206-02p 97-205-01p Aventis Rapeseed Phosphinothricin Topas 19/2 tolerant 01-137-01p Monsanto Corn Corn Rootworm MON 863 Resistant 01-121-01p Vector Tobacco Reduced nicotine Vector 21-41 00-342-01p Monsanto Cotton Lepidopteran resistant Cotton Event 15985 00-136-01p Mycogen c/o Corn Lepidopteran resistant Line 1507 Dow & Pioneer phosphinothricin tolerant 00-011-01p 97-099-01p Monsanto Corn Glyphosate tolerant NK603 99-173-01p 97-204-01p Monsanto Potato PLRV & CPB resistant RBMT22-82 98-349-01p 95-228-01p AgrEvo Corn Phosphinothricin MS6 tolerant and Male sterile 98-335-01p U. of Flax Tolerant to soil CDC Triffid Saskatchewan residues of sulfonyl urea herbicide 98-329-01p AgrEvo Rice Phosphinothricin LLRICE06, tolerant LLRICE62 98-278-01p AgrEvo Rapeseed Phosphinothricin MS8 & RF3 tolerant & Pollination control 98-238-01p AgrEvo Soybean Phosphinothricin GU262 tolerant 98-216-01p Monsanto Rapeseed Glyphosate tolerant RT73 98-173-01p Novartis Seeds & Beet Glyphosate tolerant GTSB77 Monsanto 98-014-01p 96-068-01p AgrEvo Soybean Phosphinothricin A5547-127 tolerant 97-342-01p Pioneer Corn Male sterile & 676, 678, 680 Phosphinothricin tolerant 97-339-01p Monsanto Potato CPB & PVY resistant RBMT15-101, SEMT15-02, SEMT15-15 97-336-01p AgrEvo Beet Phosphinothricin T-120-7 tolerant 97-287-01p Monsanto Tomato Lepidopteran resistant 5345 97-265-01p AgrEvo Corn Phosphinothricin CBH-351 tolerant & Lep. resistant 97-205-01p AgrEvo Rapeseed Phosphinothricin T45 tolerant 97-204-01p Monsanto Potato CPB & PLRV resistant RBMT21-129 & RBMT21-350 97-148-01p Bejo Cichorium Male sterile RM3-3, RM3-4, intybus RM3-6 97-099-01p Monsanto Corn Glyphosate tolerant GA21 97-013-01p Calgene Cotton Bromoxynil tolerant & Events 31807 & Lepidopteran resistant 31808 97-008-01p Du Pont Soybean Oil profile altered G94-1, G94-19, G- 168 96-317-01p Monsanto Corn Glyphosate tolerant & MON802 ECB resistant 96-291-01p DeKalb Corn European Corn Borer DBT418 resistant 96-248-01p 92-196-01p Calgene Tomato Fruit ripening altered 1 additional FLAVRSAVR line 96-068-01p AgrEvo Soybean Phosphinothricin W62, W98, A2704- tolerant 12, A2704-21, A5547-35 96-051-01p Cornell U Papaya PRSV resistant 55-1, 63-1 96-017-01p 95-093-01p Monsanto Corn European Corn Borer MON809 & resistant MON810 95-352-01p Asgrow Squash CMV, ZYMV, WMV2 CZW-3 resistant 95-338-01p Monsanto Potato CPB resistant SBT02-5 & -7, ATBT04-6 &-27, -30, -31, -36 95-324-01p Agritope Tomato Fruit ripening altered 35 1 N 95-256-01p Du Pont Cotton Sulfonylurea tolerant 19-51a 95-228-01p Plant Genetic Corn Male sterile MS3 Systems 95-195-01p Northrup King Corn European Corn Borer Bt11 resistant 95-179-01p 92-196-01p Calgene Tomato Fruit ripening altered 2 additional FLAVRSAVR lines 95-145-01p DeKalb Corn Phosphinothricin B16 tolerant 95-093-01p Monsanto Corn Lepidopteran resistant MON 80100 95-053-01p Monsanto Tomato Fruit ripening altered 8338 95-045-01p Monsanto Cotton Glyphosate tolerant 1445, 1698 95-030-01p 92-196-01p Calgene Tomato Fruit ripening altered 20 additional FLAVRSAVR lines 94-357-01p AgrEvo Corn Phosphinothricin T14, T25 tolerant 94-319-01p Ciba Seeds Corn Lepidopteran resistant Event 176 94-308-01p Monsanto Cotton Lepidopteran resistant 531, 757, 1076 94-290-01p Zeneca & Tomato Fruit polygalacturonase B, Da, F Petoseed level decreased 94-257-01p Monsanto Potato Coleopteran resistant BT6, BT10, BT12, BT16, BT17, BT18, BT23 94-230-01p 92-196-01p Calgene Tomato Fruit ripening altered 9 additional FLAVRSAVR lines 94-228-01p DNA Plant Tech Tomato Fruit ripening altered 1345-4 94-227-01p 92-196-01p Calgene Tomato Fruit ripening altered Line N73 1436-111 94-090-01p Calgene Rapeseed Oil profile altered pCGN3828- 212/86- 18 & 23 93-258-01p Monsanto Soybean Glyphosate tolerant 40-3-2 93-196-01p Calgene Cotton Bromoxynil tolerant BXN 92-204-01p Upjohn Squash WMV2 & ZYMV ZW-20 resistant 92-196-01p Calgene Tomato Fruit ripening altered FLAVR SAVR NOTE: To obtain the most up-to-date list of Crops No Longer Regulated, please look at the Current Status of Petitions. This list is automatically updated and reflects all petitions received to date by APHIS, including petitions pending, withdrawn, or approved. Abbreviations: CMV—cucumber mosaic virus; CPB—colorado potato beetle; PLRV—potato leafroll virus; PRSV—papaya ringspot virus; PVY—potato virus Y; WMV2—watermelon mosaic virus 2 ZYMV—zucchini yellow mosaic virus *** Extension of Petition Number: Under 7CFR 340.6(e) a person may request that APHIS extend a determination of non-regulated status to other organisms based on their similarity of the previously deregulated article. This column lists the previously granted petition of that degregulated article. **** Preliminary EA: The Environmental Assessment initially available for Public comment prior to finalization.

TABLE C Plant species Event Trait Patent reference Corn PV-ZMGT32 Glyphosate tolerance US 2007-056056 (NK603) Corn MIR604 Insect resistance (Cry3a055) EP 1 737 290 Corn LY038 High lysine content U.S. Pat. No. 7,157,281 Corn 3272 Self processing corn (alpha- US 2006-230473 amylase) Corn PV-ZMIR13 Insect resistance (Cry3Bb) US 2006-095986 (MON863) Corn DAS-59122-7 Insect resistance US 2006-070139 (Cry34Ab1/Cry35Ab1) Corn TC1507 Insect resistance (Cry1F) U.S. Pat. No. 7,435,807 Corn MON810 Insect resistance (Cry1Ab) US 2004-180373 Corn VIP1034 Insect resistance WO 03/052073 Corn B16 Glufosinate resistance US 2003-126634 Corn GA21 Glyphosate resistance U.S. Pat. No. 6,040,497 Corn GG25 Glyphosate resistance U.S. Pat. No. 6,040,497 Corn GJ11 Glyphosate resistance U.S. Pat. No. 6,040,497 Corn FI117 Glyphosate resistance U.S. Pat. No. 6,040,497 Corn GAT-ZM1 Glufosinate tolerance WO 01/51654 Corn MON87460 Drought tolerance WO 2009/111263 Corn DP-098140-6 Glyphosate tolerance/ALS WO 2008/112019 inhibitor tolerance Wheat Event 1 Fusarium resistance CA 2561992 (trichothecene 3-O- acetyltransferase) Sugar beet T227-1 Glyphosate tolerance US 2004-117870 Sugar beet H7-1 Glyphosate tolerance WO 2004-074492 Soybean MON89788 Glyphosate tolerance US 2006-282915 Soybean A2704-12 Glufosinate tolerance WO 2006/108674 Soybean A5547-35 Glufosinate tolerance WO 2006/108675 Soybean DP-305423-1 High oleic acid/ALS inhibitor WO 2008/054747 tolerance Rice GAT-OS2 Glufosinate tolerance WO 01/83818 Rice GAT-OS3 Glufosinate tolerance US 2008-289060 Rice PE-7 Insect resistance (Cry1Ac) WO 2008/114282 Oilseed rape MS-B2 Male sterility WO 01/31042 Oilseed rape MS-BN1/RF-BN1 Male sterility/restoration WO 01/41558 Oilseed rape RT73 Glyphosate resistance WO 02/36831 Cotton CE43-67B Insect resistance (Cry1Ab) WO 2006/128573 Cotton CE46-02A Insect resistance (Cry1Ab) WO 2006/128572 Cotton CE44-69D Insect resistance (Cry1Ab) WO 2006/128571 Cotton 1143-14A Insect resistance (Cry1Ab) WO 2006/128569 Cotton 1143-51B Insect resistance (Cry1Ab) WO 2006/128570 Cotton T342-142 Insect resistance (Cry1Ab) WO 2006/128568 Cotton event3006-210-23 Insect resistance (Cry1Ac) WO 2005/103266 Cotton PV-GHGT07 (1445) Glyphosate tolerance US 2004-148666 Cotton MON88913 Glyphosate tolerance WO 2004/072235 Cotton EE-GH3 Glyphosate tolerance WO 2007/017186 Cotton T304-40 Insect-resistance (Cry1Ab) WO2008/122406 Cotton Cot202 Insect resistance (VIP3) US 2007-067868 Cotton LLcotton25 Glufosinate resistance WO 2007/017186 Cotton EE-GH5 Insect resistance (Cry1Ab) WO 2008/122406 Cotton event 281-24-236 Insect resistance (Cry1F) WO 2005/103266 Cotton Cot102 Insect resistance (Vip3A) US 2006-130175 Cotton MON 15985 Insect resistance (Cry1A/ US 2004-250317 Cry2Ab) Bent Grass Asr-368 Glyphosate tolerance US 2006-162007 Brinjal EE-1 Insect resistance (Cry1Ac) WO 2007/091277

The composition according to the invention may also be used against fungal diseases liable to grow on or inside timber. The term “timber” means all types of species of wood, and all types of working of this wood intended for construction, for example solid wood, high-density wood, laminated wood, and plywood. The method for treating timber according to the invention mainly consists in contacting one or more compounds according to the invention or a composition according to the, invention; this includes for example direct application, spraying, dipping, injection or any other suitable means.

Among the diseases of plants or crops that can be controlled by the method according to the invention, mention can be made of

Powdery Mildew Diseases such as

-   Blumeria diseases caused for example by Blumeria graminis; -   Podosphaera diseases caused for example by Podosphaera, leucotricha; -   Sphaerotheca diseases caused for example by Sphaerotheca fuliginea; -   Uncinula diseases caused for example by Uncinula necator;

Rust Diseases such as

-   Gymnosporangium diseases caused for example by Gymnosporangium     sabinae; -   Hemileia diseases caused for example by Hemileia vastatrix; -   Phakopsora diseases caused for example by Phakopsora pachyrhizi and     Phakopsora meibomiae; -   Puccinia diseases caused for example by Puccinia recondita, Puccinia     graminis or Puccinia striiformis; -   Uromyces diseases caused for example by Uromyces appendiculatus;

Oomycete Diseases such as

-   Albugo diseases caused for example by Albugo candida; -   Bremia diseases caused for example by Bremia lactucae; -   Peronospora diseases caused for example by Peronospora pisi and     Peronospora brassicae; -   Phytophthora diseases caused for example by Phytophthora infestans; -   Plasmopara diseases caused for example by Plasmopara viticola; -   Pseudoperonospora diseases caused for example by Pseudoperonospora     humuli and Pseudo-peronospora cubensis; -   Pythium diseases caused for example by Pythium ultimum;

Leaf spot, Leaf blotch and Leaf Blight Diseases such as

-   Alternaria diseases caused for example by Alternaria solani; -   Cercospora diseases caused for example by Cercospora beticola; -   Cladiosporium diseases caused for example by Cladiosporium     cucumerinum; -   Cochliobolus diseases caused for example by Cochliobolus sativus     (Conidiaform: Drechslera, Syn: Helminthosporium) or Cochliobolus     miyabeanus; -   Colletotrichum diseases caused for example by Colletotrichum     lindemuthianum; -   Cycloconium diseases caused for example by Cycloconium oleaginum; -   Diaporthe diseases caused for example by Diaporthe citri; -   Elsinoe diseases caused for example by Elsinoe fawcettii; -   Gloeosporium diseases caused for example by Gloeosporium laeticolor; -   Glomerella diseases caused for example by Glomerella cingulata; -   Guignardia diseases caused for example by Guignardia bidwellii; -   Leptosphaeria diseases caused for example by Leptosphaeria maculans     and Leptosphaeria nodorum; -   Magnaporthe diseases caused for example by Magnaporthe grisea; -   Mycosphaerella diseases caused for example by Mycosphaerella     graminicola, Mycosphaerella arachidicola and Mycosphaerella     fijiensis; -   Phaeosphaeria diseases caused for example by Phaeosphaeria nodorum; -   Pyrenophora diseases caused for example by Pyrenophora teres or     Pyrenophora tritici repentis; -   Ramularia—diseases caused for example by Ramularia collo-cygni or     Ramularia areola; -   Rhynchosporium diseases caused for example by Rhynchosporium     secalis; -   Septoria diseases caused for example by Septoria apii and Septoria     lycopersici; -   Typhula diseases caused for example by Thyphula incarnata; -   Venturia diseases caused for example by Venturia inaequalis;

Root—, Sheath and Stem Diseases such as

-   Corticium diseases caused for example by Corticium graminearum; -   Fusarium diseases caused for example by Fusarium oxysporum; -   Gaeumannomyces diseases caused for example by Gaeumannomyces     graminis; -   Rhizoctonia diseases caused for example by Rhizoctonia solani; -   Sarocladium diseases caused for example by Sarocladium oryzae; -   Sclerotium diseases caused for example by Sclerotium oryzae; -   Tapesia diseases caused for example by Tapesia acuformis; -   Thielaviopsis diseases caused for example by Thielaviopsis basicola;

Ear and Panicle Diseases including Maize cob such as

-   Alternaria diseases caused for example by Alternaria spp.; -   Aspergillus diseases caused for example by Aspergillus flavus; -   Cladosporium diseases caused for example by Cladiosporium     cladosporioides; -   Claviceps diseases caused for example by Claviceps purpurea; -   Fusarium diseases caused for example by Fusarium culmorum; -   Gibberella diseases caused for example by Gibberella zeae; -   Monographella diseases caused for example by Monographella nivalis;

Smut- and Bunt Diseases such as

-   Sphacelotheca diseases caused for example by Sphacelotheca reiliana; -   Tilletia diseases caused for example by Tilletia caries; -   Urocystis diseases caused for example by Urocystis occulta; -   Ustilago diseases caused for example by Ustilago nuda;

Fruit Rot and Mould Diseases such as

-   Aspergillus diseases caused for example by Aspergillus flavus; -   Botrytis diseases caused for example by Botrytis cinerea; -   Penicillium diseases caused for example by Penicillium expansum and     Penicillium purpurogenum; -   Rhizopus diseases caused by example by Rhizopus stolonifer -   Sclerotinia diseases caused for example by Sclerotinia sclerotiorum; -   Verticillium diseases caused for example by Verticillium alboatrum;

Seed- and Soilborne Decay, Mould, Wilt, Rot and Damping-off diseases

-   Alternaria diseases caused for example by Alternaria brassicicola; -   Aphanomyces diseases caused for example by Aphanomyces euteiches; -   Ascochyta diseases caused for example by Ascochyta lentis; -   Aspergillus diseases caused for example by Aspergillus flavus; -   Cladosporium diseases caused for example by Cladosporium herbarum; -   Cochliobolus diseases caused for example by Cochliobolus sativus; -   (Conidiaform: Drechslera, Bipolaris Syn: Helminthosporium); -   Colletotrichum diseases caused for example by Colletotrichum     coccodes; -   Fusarium diseases caused for example by Fusarium culmorum; -   Gibberella diseases caused for example by Gibberella zeae; -   Macrophomina diseases caused for example by Macrophomina phaseolina; -   Microdochium diseases caused for example by Microdochium nivale; -   Monographella diseases caused for example by Monographella nivalis; -   Penicillium diseases caused for example by Penicillium expansum; -   Phoma diseases caused for example by Phoma lingann; -   Phomopsis diseases caused for example by Phomopsis sojae; -   Phytophthora diseases caused for example by Phytophthora cactorum; -   Pyrenophora diseases caused for example by Pyrenophora graminea; -   Pyricularia diseases caused for example by Pyricularia oryzae; -   Pythium diseases caused for example by Pythium ultimum; -   Rhizoctonia diseases caused for example by Rhizoctonia solani; -   Rhizopus diseases caused for example by Rhizopus oryzae; -   Sclerotium diseases caused for example by Sclerotium rolfsii; -   Septoria diseases caused for example by Septoria nodorum; -   Typhula diseases caused for example by Typhula incarnata; -   Verticillium diseases caused for example by Verticillium dahliae;

Canker, Broom and Dieback Diseases such as

-   Nectria diseases caused for example by Nectria galligena;

Blight Diseases such as

-   Monilinia diseases caused for example by Monilinia laxa;

Leaf Blister or Leaf Curl Diseases including deformation of blooms and fruits such as

-   Exobasidium diseases caused for example by Exobasidium vexans. -   Taphrina diseases caused for example by Taphrina deformans;

Decline Diseases of Wooden Plants such as

-   Esca disease caused for example by Phaeornoniella clannydospora,     Phaeoacremonium aleophilum and Fomitiporia mediterranea; -   Ganoderma diseases caused for example by Ganoderrna boninense; -   Rigidoporus diseases caused for example by Rigidoporus lignosus

Diseases of Flowers and Seeds such as

-   Botrytis diseases caused for example by Botrytis cinerea;

Diseases of Tubers such as

-   Rhizoctonia diseases caused for example by Rhizoctonia solani; -   Helminthosporium diseases caused for example by Helminthosporium     solani;

Club root diseases such as

-   Plasmodiophora diseases, cause for example by Plamodiophora     brassicae.

Diseases caused by Bacterial Organisms such as

-   Xanthomonas species for example Xanthomonas campestris pv. oryzae; -   Pseudomonas species for example Pseudomonas syringae pv. lachrymans; -   Erwinia species for example Erwinia amylovora.

The damaging insects of crops which can be controlled at any development stage by using the pesticide composition according to the invention, include:

-   -   pests from the order of Isopoda for example Oniscus asellus,         Armadillidium vulgare, Porcellio scaber;     -   pests from the order of Diplopoda for example Blaniulus         guttulatus;     -   pests from the order of Chilopoda for example Geophilus         carpophagus, Scutigera spp.;     -   pests from the order of Symphyla for example Scutigerella         immaculata;     -   pests from the order of Thysanura for example Lepisma         saccharina;     -   pests from the order of Collembola for example Onychiurus         armatus;     -   pests from the order of Orthoptera for example Acheta         domesticus, Gryllotalpa spp., Locusta migratoria migratorioides,         Melanoplus spp., Schistocerca gregaria;     -   pests from the order of Blattaria for example Blatta orientalis,         Periplaneta americana, Leucophaea maderae, Blattella germanica;     -   pests from the order of Dermaptera for example Forficula         auricularia;     -   pests from the order of Isoptera for example Reticulitermes         spp.;     -   pests from the order of Phthiraptera for example Pediculus         humanus corporis, Haematopinus spp., Linognathus spp.,         Trichodectes spp., Damalinia spp.;     -   pests from the order of Thysanoptera for example Hercinothrips         femoralis, Thrips tabaci, Thrips palmi, Frankliniella         accidentalis;     -   pests from the order of Heteroptera for example Eurygaster spp.,         Dysdercus intermedius, Piesma quadrata, Cimex lectularius,         Rhodnius prolixus, Triatoma spp;     -   pests from the order of Hornoptera for example Aleurodes         brassicae, Bemisia tabaci, Trialeurodes vaporariorum, Aphis         gossypii, Brevicoryne brassicae, Cryptornyzus ribis, Aphis         fabae, Aphis porni, Eriosoma lanigerum, Hyalopterus arundinis,         Phylloxera vastatrix, Pemphigus spp., Macrosiphum avenae, Myzus         spp., Phorodon humuli, Rhopalosiphum padi, Empoasca spp.,         Euscelis bilobatus, Nephotettix cincticeps, Lecanium corni,         Saissetia oleae, Laodelphax striatellus, Nilaparvata lugens,         Aonidiella aurantii, Aspidiotus hederae, Pseudococcus spp.,         Psylla spp;     -   pests from the order of Lepidoptera for example Pectinophora         gossypiella, Bupalus piniarius, Cheimatobia brumata,         Lithocolletis blancardella, Hyponomeuta padella, Plutella         xylostella, Malacosoma neustria, Euproctis chrysorrhoea,         Lymantria spp., Bucculatrix thurberiella, Phyllocnistis         citrella, Agrotis spp., Euxoa spp., Feltia spp., Earias         insulana, Heliothis spp., Mamestra brassicae, Panolis flammea,         Spodoptera spp., Trichoplusia ni, Carpocapsa pomonella, Pieris         spp., Chilo spp., Pyrausta nubilalis, Ephestia kuehniella,         Galleria mellonella, Tineola bisselliella, Tinea pellionella,         Hofmannophila pseudospretella, Cacoecia podana, Capua         reticulana, Choristoneura fumiferana, Clysia ambiguella, Homona         magnanima, Tortrix viridana, Cnaphalocerus spp., Oulema oryzae;     -   pests from the order of Coleoptera for example Anobium         punctatum, Rhizopertha dominica, Bruchidius obtectus,         Acanthoscelides obtectus, Hylotrupes bajulus, Agelastica alni,         Leptinotarsa decemlineata, Phaedon cochleariae, Diabrotica spp.,         Psylliodes chrysocephala, Epilachna varivestis, Atomaria spp.         oryzaephilus surinamensis, Anthonomus spp., Sitophilus spp.,         Otiorrhynchus sulcatus, Cosmopolites sordidus, Ceuthorrhynchus         assimilis, Hypera, postica, Dermestes spp., Trogoderma spp.,         Anthrenus spp., Attagenus, spp., Lyctus spp., Meligethes aeneus,         Ptinus spp., Niptus hololeucus, Gibbium psylloides, Tribolium         spp., Tenebrio molitor, Agriotes spp., Conoderus spp.,         Melolontha melolontha, Amphimallon solstitialis, Costelytra         zealandica, Lissorhoptrus oryzophilus;     -   pests from the order of Hymenoptera for example Diprion spp.,         Hoplocampa spp., Lasius spp., Monomorium pharaonis, Vespa spp;     -   pests from the order of Diptera for example Aedes spp.,         Anopheles spp., Culex spp., Drosophila melanogaster, Musca spp.,         Fannia spp., Calliphora erythrocephala, Lucilia spp., Chrysomyia         spp., Cuterebra spp., Gastrophilus spp., Hyppobosca spp.,         Stomoxys spp., Oestrus spp., Hypoderma spp., Tabanus spp.,         Tannia spp., Bibio hortulanus, Oscinella frit, Phorbia spp.,         Pegomyia hyoscyami, Ceratitis capitata, Dacus oleae, Tipula         paludosa, Hylemyia spp., Liriomyza spp.;     -   pests from the order of Siphonaptera for example Xenopsylla         cheopis, Ceratophyllus spp.;     -   pests from the class of Arachnida for example Scorpio maurus,         Latrodectus mactans, Acarus siro, Argas spp. ornithodoros spp.,         Dermanyssus gallinae, Eriophyes ribis, Phyllocoptruta oleivora,         Boophilus spp., Rhipicephalus spp., Amblyomma spp., Hyalomma         spp., Ixodes spp., Psoroptes spp., Chorioptes spp., Sarcoptes         spp., Tarsonemus spp., Bryobia praetiosa, Panonychus spp.,         Tetranychus spp., Hemitarsonemus spp., Brevipalpus spp;     -   the plant-parasitic nematodes such as Pratylenchus spp.,         Radopholus similis, Ditylenchus dipsaci, Tylenchulus         semipenetrans, Heterodera spp., Globodera spp., Meloidogyne         spp., Aphelenchoides spp., Longidorus spp., Xiphinema spp.,         Trichodorus spp., Bursaphelenchus spp.

As a further aspect, the present invention provides products comprising compounds (A) and (B); (A), (B) and (C); (A), (B)and (D); or (A), (B), (C) and (D) as herein defined, as a combined preparation for simultaneous, separate or sequential use in controlling the phytopathogenic fungi or damaging insects of plants, crops or seeds at a site.

The pesticide composition according to the invention can be prepared immediately before use by using a kit-of-parts for controlling, curatively or preventively, the phytopathogenic fungi of crops, such a kit-of-parts may comprise at least one or several compounds (A), (B), (C) and/or (D) intended to be combined or used simultaneously, separately or sequentially in controlling the phytopathogenic fungi of crops at a site.

It is therefore a pack wherein the user finds all the ingredients for preparing the, fungicide formulation which they wish, to apply to the crops. These ingredients, which comprise in particular the active agents (A), (B), (C) and/or (D) and which are packaged, separately, are provided in the form of a powder or in the form of a liquid which is concentrated to a greater or lesser degree. The user simply has to mix in the prescribed doses and to add the quantities of liquid, for example of water, necessary to obtain a formulation which is ready to use and which can be applied to the crops.

The advanced fungicidal activity of the active compound combinations according to the invention is evident from the example below. While the individual active compounds exhibit weaknesses with regard to the fungicidal activity, the combinations have an activity which exceeds a simple addition of activities.

A synergistic effect of fungicides is always present when the fungicidal activity of the active compound combinations exceeds the total of the activities of the active compounds when applied individually. The expected activity for a given combination of two active compounds can be calculated as follows (cf. Colby, S. R., “Calculating Synergistic and Antagonistic Responses of Herbicide Combinations”, Weeds 1967, 15, 20-22):

If

-   -   X is the efficacy when active, compound A is applied at an,         application rate of m ppm (or g/ha),     -   Y is the efficacy when active compound B is applied at an         application rate of n ppm (or g/ha),     -   E is the efficacy when the active compounds A and B are applied         at application rates of m and n ppm (or g/ha), respectively, and

then

$E = {X + Y - \frac{X \cdot Y}{100}}$

The degree of efficacy, expressed in % is denoted. 0% means an efficacy which corresponds to that of the control while an efficacy of 100% means that no disease is observed.

If the actual fungicidal activity exceeds the calculated value, then the activity of the combination is superadditive, i.e. a synergistic effect exists. In this case, the efficacy which was actually observed must be greater than the value for the expected efficacy (E) calculated from the abovementioned formula.

A further way of demonstrating, a synergistic effect is the method of Tammes (cf. “Isoboles, a graphic representation of synergism in, pesticides” in Neth. J. Plant Path., 1964, 70, 73-80).

The invention is illustrated by the following example. However the invention is not limited to the examples.

Example

Phytophthora Test (Tomatoes)/Preventive

Solvent: 24,5 parts by weight of acetone

-   -   24,5 parts by weight of dimethylacetamide

Emulsifier: part by weight of alkylaryl polyglycol ether

To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

To test for preventive activity, young plants are sprayed with the preparation of active compound at the stated rate of application. After the spray coating has dried on the plants are inoculated with an aqueous spore suspension of Phytophthora infestans. The plants are then placed in an incubation cabinet at approximately 20° C. and a relative atmospheric humidity of 100%.

The test is evaluated 3 days after the inoculation. 0% means an efficacy which corresponds to that of the untreated control, while an efficacy of 100% means that no disease is observed.

The table below clearly shows that the observed activity of the active compound combination according to the invention is greater than the calculated activity, i.e. a synergistic effect is present.

TABLE Phytophthora test (tomatoes)/protective Application rate of active compound in Efficacy in % Active compounds ppm a.i. found* calc.** (A2) tert-butyl {6-[({[(Z)-(1-methyl-1H- 1 46 tetrazol-5-yl)(phenyl)methylene]- amino}oxy)methyl]pyridin-2-yl}- carbamate (B2) 1-(4-{4-[5-(2,6-difluorophenyl)-4,5- 0.01 30 dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2- yl}piperidin-1-yl)-2-[5-methyl-3- (trifluoromethyl)-1H-pyrazol-1-yl]- ethanone (A2) + (B2) 100:1 1 + 0.01 73 62 *found = activity found **calc. = activity calculated using Colby's formula

Example

Venturia Test (Apples)/Preventive

Solvent: 24,5 parts by weight of acetone

-   -   24,5 parts by weight of dimethylacetamide

Emulsifier: part by weight of alkylaryl polyglycol ether

To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

To test for preventive activity, young plants are sprayed with the preparation of active compound at the stated rate of application. After the spray coating has dried on the plants are inoculated with an aqueous conidia suspension of the causal agent of apple scab (Venturia inaequalis) and then remain for 1 day in an incubation cabinet at approximately 20° C. and a relative atmospheric humidity of 100%.

The plants are then placed in a greenhouse at approximately 21° C. and a relative atmospheric humidity of approximately 90%.

The test is evaluated 10 days after the inoculation. 0% means an efficacy which corresponds to that of the untreated control, while an efficacy of 100% means that no disease is observed.

The table below clearly shows that the observed activity of the active compound combination according to the invention is greater than the calculated activity, i.e. a synergistic effect is present.

TABLE Venturia test (apples)/preventive Application rate of active compound in Efficacy in % Active compounds ppm a.i. found* calc.** (A2) tert-butyl {6-[({[(Z)-(1-methyl-1H- 100 22 tetrazol-5-yl)(phenyl)methylene]- amino}oxy)methyl]pyridin-2-yl}- carbamate (B2) 1-(4-{4-[5-(2,6-difluorophenyl)-4,5- 100 0 dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2- yl}piperidin-1-yl)-2-[5-methyl-3- (trifluoromethyl)-1H-pyrazol-1-yl]- ethanone (A2) + (B2) 1:1 100 + 100 56 22 *found = activity found **calc. = activity calculated using Colby's formula 

The invention claimed is:
 1. A composition comprising: A) a tetrazolyloxime derivative of formula (I)

wherein R¹ independently represents a hydrogen atom; q represents 0, 1, 2, 3, 4 or 5; A represents a tetrazoyl group of formula (A¹):

wherein Y represents an C₁-C₆-alkyl group; and D represents a pyridyl group of formula (D¹);

wherein R² represents a hydrogen atom; wherein n represents 0, 1, 2 or 3; wherein Z represents Q¹CONH—, wherein Q¹ represents a non-substituted C₁-C₈-alkyl, or non-substituted C₁-C₈-alkoxy; as well as salts, N-oxides, metallic complexes and metalloidic complexes thereof or (E) and (Z) isomers and mixtures thereof and B) a thiazolylpiperidine derivative of formula (II)

wherein R⁴ independently represents a hydrogen atom, a halogen atom, a C₁-C₆-alkyl, a C₁-C₆-alkoxy, a C₁-C₆-haloalkyl comprising between one and 5 halogen atoms, cyano; u represents 1, 2, 3, 4 or 5; as well as salts, N-oxides, metallic complexes and metalloidic complexes thereof or optically active isomers and mixtures thereof; in an A/B weight ratio ranging from 1,000/1 to 1/1,000.
 2. A composition according to claim 1 wherein Y represents a methyl group.
 3. A composition according to claim 1 wherein R⁴ independently represents a hydrogen atom or a halogen atom.
 4. A composition according to claim 1 wherein R⁴ represents a hydrogen atom or a fluorine.
 5. A composition according to claim 1 wherein the tetrazolyloxime derivative of formula (I) is tert-butyl{6-[{]([(Z)-(1-methyl-1H-tetrazol-5-yl) (phenyl)methylene]amino}oxy)methyl pyridin-2-yl}carbamate.
 6. A composition according to claim 1 wherein the thiazolylpiperidine derivative of formula (II) is 2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-(5-phenyl-4,5-dihydro-1,2-oxazol-3 -yl)-1,3-thiazol-2]piperidin-1-yl}ethanone or 1-(4-{4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone.
 7. A composition according to claim 1 further comprising C) a third fungicide compound, in an A/B/C weight ratio ranging from 1,000/1,000/1 to 1/1,000/1,000.
 8. A composition according to claim 1 further comprising D) an insecticide compound, in an A/B/D weight ratio ranging from 1,000/1,000/1 to 1/1,000/1,000.
 9. A composition according to claim 1 further comprising C) a third further fungicide compound and D) an insecticide compound, in an A/B/C/D weight ratio ranging from 1,000/1,000/1,000/1 to 1/1,000/1,000/1,000.
 10. A method for controlling the phytopathogenic fungi or damaging insects of plants, crops or seeds comprising the step of applying an agronomically effective and substantially non-phytotoxic quantity of a pesticide composition according to claim 1 as seed treatment, foliar application, stem application, drench or drip application or chemigation to the seed, the plant or to the fruit of the plant or to soil or to inert substrate, Pumice, Pyroclastic materials or stuff, synthetic organic substrates organic substrates or to a liquid substrate wherein the plant is growing or wherein it is desired to grow.
 11. A composition according to claim 1, wherein Y is a methyl group, Q¹ is a non -substituted C₁-C₆-alkoxy and R⁴ is a hydrogen or halogen atom.
 12. A composition according to claim 1, wherein Y is a methyl group, Q¹ is a non -substituted C₁-C₆-alkoxy and R⁴ is a hydrogen or halogen atom and u is
 2. 13. Acomposition according to claim 1, wherein the tetrazolyoxime derivative of formula (I) is tert-butyl tert-butyl{6-[({[(Z)-(1-methyl-1H-tetrazol -5-yl) (phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate and the thiazolylpiperidine derivative of formula (II) is 1-(4-{4-[5-(2,6-difluorophenyl) -4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone. 